Pravastatin Reduces Acute Phase Response of Zoledronic Acid

Status Not yet recruiting

Clinical Trial Summary

Acute phase response (APR) is one of the most common adverse events in osteoporosis with zoledronic acid treatment. It's reported that this reaction is related to the blockade of the mevalonate pathway, leading to isopentenyl pyrophosphate (IPP) accumulation. And the latter can active γδT cells in the circulation, resulting in inflammatory cytokine release. Statins can inhibit the conversion of HMG-CoA to mevalonate that may reduce the accumulation of IPP. Therefore, it is possible that statins can be taken in advance to reduce APR caused by zoledronic acid infusion.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04719481
Study type	Interventional
Source	Peking University Third Hospital
Contact	Qi Liu, Ph. D.
Phone	+8615501060136
Email	liuqicpu@hotmail.com
Status	Not yet recruiting
Phase	Phase 4
Start date	November 2021
Completion date	April 2022

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