Correlation Between Thermal Patterns of Infrared Thermal Imaging and Clinical Phenotype in Patients With Postherpetic Neuralgia

Postherpetic Neuralgia Clinical Trial

Official title:

Correlation Between Different Thermal Patterns of Infrared Thermal Imaging and Clinical Phenotype and Prognosis in Patients With Postherpetic Neuralgia

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05568186
• Other study ID #: postherpetic neuralgia
• Status: Recruiting
• Start date: October 1, 2022
• Est. completion date: October 1, 2023

Study information

• Verified date: October 2022
• Source: Huazhong University of Science and Technology
• Contact: Xianwei Zhang, Doctor
• Phone: (+86)13037154560
• Email: ourpain[@]163.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Postherpetic neuralgia (PHN) is the most frequent complication of herpes zoster(HZ) and is defined as pain persisting for >1month after the healing of herpetic skin lesion or pain persisting for > 3 months following the onset of HZ. PHN manifests as spontaneous throbbing, stabbing, or burning, usually accompanied by various abnormal sensory symptoms , which affect 5-20% of patients with HZ. Due to the lack of accurate and objective auxiliary examination tools, it is difficult for diagnosis and treatment of PHN. As a non-invasive examination method, infrared thermal imaging (IRT) can play a role in the diagnosis and treatment of neuropathic pain by objectively reflecting the changes and distribution characteristics of human body surface temperature. However, there are few studies on the relationship between clinical phenotype and thermal infrared image temperature changes in PHN patients, and the relationship between the thermal pattern of skin temperature and the duration of disease and treatment progress in PHN patients has not been fully elucidated. This study was conducted to investigate the relationship of thermal imaging data with the duration of the disease, clinical phenotype, treatment effect, in order to explore the role of infrared thermal imaging in the diagnosis and treatment of PHN. Methods：all PHN patients will included. At each visit, a pain NRS score was performed, and clinical phenotypes were tested and labeled, including: allodynia, numbness, itching, heat sensation, cold sensation, and the most painful area(MPA). Infrared thermal imaging was performed, the Average Relative Temperature (ART) within the affected area and the contralateral area was compared. The relationship between the temperature change and duration of the disease, clinical phenotype, treatment effect was assessed.

Description:

patients with the follow conditions were excluded: 1)The skin area was lesions because of other disease(trauma, inflammation, skin scar, skin disease, tumor, etc.); 2) history of psychiatric diseases, chronic pain. 3) inabilities to complete IRT examination.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 166
• Est. completion date: October 1, 2023
• Est. primary completion date: October 1, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• 1) patients>18 years-old 2) pain lasts at least 1 month after lesion crusting 3) Agreed to participate the research

Exclusion Criteria:

• 1))the skin area was lesions because of other disease(trauma, inflammation, skin scar, skin disease, tumor, etc.); 2) history of psychiatric diseases, chronic pain. 3)inabilities to complete IRT examination. 4) Disagree to participate to the research

Related Conditions & MeSH terms

• Neuralgia
• Neuralgia, Postherpetic
• Postherpetic Neuralgia

Locations

Country	Name	City	State
China	Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology	Wuhan	Hubei

Sponsors (1)

Lead Sponsor	Collaborator
Xianwei Zhang,MD

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Thermal pattern difference between affected side and contralateral side	Thermal pattern difference between affected side and contralateral side	1 year
Primary	temperature difference between affected side and contralateral side	temperature difference between affected side and contralateral side	1 year
Secondary	the relationship between the temperature change and disease duration	the relationship between the temperature change and disease duration	1 year
Secondary	the relationship between the temperature change and Pain Scores on Visual Analog Scale at each visit	the relationship between the temperature change and Pain Scores on Visual Analog Scale at each visit	1 year
Secondary	the relationship between the temperature change and clinical phenotype	the relationship between the temperature change and clinical phenotype	1 year
Secondary	the relationship between the temperature change and treatment effect	the relationship between the temperature change and treatment effect	1 year