Postherpetic Neuralgia Clinical Trial
Official title:
Randomized Double Blind Placebo Controlled Multicenter Study of the Efficacy and Safety of Repeated Administrations of Botulinum Toxin Type A (Botox) in the Treatment of Peripheral Neuropathic Pain
Pain due to peripheral nerve lesion remains extremely difficult to treat and current treatments have onl moderate efficacy and/or side effects. The investigators have previously demonstrated the long term efficacy of Botulinum toxin type A (BTX-A) in a small group of patients with post-traumatic/postherpetic neuralgia and allodynia. The present study aims to a/ confirm the efficacy of repeated applications of BTX-A in a larger group of patients with peripheral neuropathic pain with or without allodynia(primary outcome) ; b/ evaluate its mechanisms of action ; c/analyse the predictors of response ;d/analyse whether the second injection is associated with a therapeutic gain. This will be a randomized placebo controlled study. A total of 30 patients will be randomized to receive either BTX-A (subcutaneous injection in the painful area) or placebo. Each injection will be repeated within at least 3 months depending on the duration of efficacy. Skin punch biopsies will be performed before and 1 month after BTX-A administration. The investigators postulate that this study will confirm the clinical efficacy and good safety of repeated administrations of BTX-A in the treatment of peripheral neuropathic pain.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04546334 -
Erector Spinae Plane Block in Post-herpetic Neuralgia
|
N/A | |
Terminated |
NCT01744522 -
Leech Therapy for Postherpetic Neuralgia
|
N/A | |
Completed |
NCT01688947 -
Analgesic Efficacy and Safety of V116517 in Subjects With Moderate to Severe Chronic Pain Due to Postherpetic Neuralgia (PHN)
|
Phase 2 | |
Completed |
NCT00566904 -
New Topical Treatment for Continued Pain After Shingles
|
Phase 1 | |
Completed |
NCT00478179 -
Study of a Bupivacaine Patch (Eladurâ„¢) to Treat Post- Herpetic Neuralgia
|
Phase 2 | |
Completed |
NCT04099706 -
Treatment of Chronic Postherpetic Pain With Autologous Fat Grafting - A RCT
|
N/A | |
Terminated |
NCT01603394 -
Pilot Study Of Pregabalin And Prediction Of Treatment Response In Patients With Postherpetic Neuralgia
|
Phase 4 | |
Completed |
NCT01228838 -
Study of NGX-1998 for the Treatment of Postherpetic Neuralgia
|
Phase 2 | |
Completed |
NCT00612105 -
Safety/Efficacy Study of Retigabine vs. Placebo in Post-Herpetic Neuralgia (PHN)
|
Phase 2 | |
Recruiting |
NCT04560361 -
The Analgesic Effect of Electroacupuncture on Postherpetic Neuralgia
|
N/A | |
Recruiting |
NCT05568186 -
Correlation Between Thermal Patterns of Infrared Thermal Imaging and Clinical Phenotype in Patients With Postherpetic Neuralgia
|
||
Recruiting |
NCT04664530 -
The Study on the Esketamine in the Treatment of Postherpetic Neuralgia
|
Phase 4 | |
Active, not recruiting |
NCT01508676 -
Effects of Pennsaid on Clinical Neuropathic Pain
|
N/A | |
Completed |
NCT00885586 -
Acupuncture in Herpes Zoster Neuralgia (ACUZoster)
|
Phase 4 | |
Completed |
NCT00576108 -
A 2 Week Study of Topical KD7040 in the Treatment of Postherpetic Neuralgia (PHN)
|
Phase 2 | |
Completed |
NCT00981227 -
Efficacy and Safety of Eslicarbazepine Acetate as Therapy for Patients With Post-Herpetic Neuralgia
|
Phase 2 | |
Completed |
NCT00238511 -
An Open-Label Follow-on Trial to Assess the Long-Term Safety and Efficacy of Oral SPM 927 in Subjects With Postherpetic Neuralgia (PHN)
|
Phase 2 | |
Completed |
NCT00007501 -
Shingles Prevention Study
|
Phase 3 | |
Completed |
NCT04594226 -
Electroacupuncture Therapy for Treating Postherpetic Neuralgia
|
N/A | |
Completed |
NCT05140863 -
To Evaluate the Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Postherpetic Neuralgia
|
Phase 3 |