Development of the Effectiveness of Rehabilitation Tools for Neurovisual Disorders in Patients With Posterior Cortical Atrophy

Posterior Cortical Atrophy Clinical Trial

— REEDUC-ACP  

Official title:

Development and Evaluation of the Effectiveness of Rehabilitation Tools for Neurovisual Disorders in Patients With Posterior Cortical Atrophy (PCA)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04041089
• Other study ID #: 18-AOI-02
• Status: Completed
• Phase: N/A
• Start date: September 2, 2019
• Est. completion date: June 15, 2022

Study information

• Verified date: February 2023
• Source: Centre Hospitalier Universitaire de Nice
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Posterior cortical atrophy (PCA) is manifested by neuro-visual disorders that alter the spatial location of objects, their manipulation and/or recognition. Its etiology is most often neurodegenerative, with a major impact on the autonomy and mood of patients and their families. Few studies have focused on non-medication management of these disorders.

The present study thus has a double objective: the development of a complete tool to work on the recognition, localization and/or manipulation of objects; and the evaluation of the effectiveness of this type of management.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 3
• Est. completion date: June 15, 2022
• Est. primary completion date: June 15, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 50 Years and older

Eligibility

Inclusion Criteria:

• Age >50 years old

• Male or Female

• Patients with a diagnosis of PCA according to the criteria of Tang-Wai et al (2004)

• MMS>15

• Voluntary, written and informed consent of the patient himself or its legal representative (guardian/curator), with oral consent of the patient in all cases

• Anti-Alzheimer's and psychotropic treatments stable for one month, if taken by the patient

• Affiliation to a social security system

Exclusion Criteria:

• Uncorrected visual disorders with non-degenerative etiology (AV<0.5)

• Person under the protection of justice

• Pregnant women (a pregnancy test will be performed in premenopausal women)

Related Conditions & MeSH terms

• Atrophy
• Posterior Cortical Atrophy

Intervention

Behavioral:
• Recognition of objects
Name of shapes / colors / images / objects Classification of shapes / colors / images / objects
• Location of objects
Search for frequent/rarse targets among distractors sharing one or more characteristics with the target Hit/catch a stationary/mobile target as quickly as possible
• Manipulation of objects
Storage of shapes/objects Use of everyday objects (pen, cutlery, etc.)

Locations

Country	Name	City	State
France	Institut Claude Pompidou - Centre Mémoire de Ressources et de Recherche du CHU de Nice	Nice	Alpes-Maritime

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Nice

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Effectiveness evaluation	Effectiveness will be evaluated a score based on success rate (from 0 to 10), reaction time and eye-recording .	At week 34