Abobotulinumtoxina Efficacy in Post-Traumatic Headache

Status Completed

Clinical Trial Summary

This study will evaluate the efficacy of abobotulinumtoxina on Veterans with post-traumatic headache

Clinical Trial Description

A significant proportion of headaches occur following head trauma, and therefore are referred to as post-traumatic headaches (PTH). Traumatic brain injury (TBI) is highly prevalent in the Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) population and consequently there has been a rise in PTH in the clinical setting at VA hospitals. Botulinum toxin type A (BoNT-A) has been shown to be effective in treating chronic migraine and chronic daily headache. It is therefore reasonable to predict that BoNT-A may also be effective in treating PTH. This study proposes that PTH and its associated symptoms may respond positively to BoNT-A treatment due to its similar pathophysiology and clinical resemblance to other headache disorders including tension type headache, typical migraine with or without aura, and chronic daily headache.

Study Design: Veterans with mild, moderate or severe brain injury with a headache developing within 7 days after head trauma and persisting greater than 3 months were recruited from the Veterans Affairs Greater Los Angeles Healthcare System. The study is a prospective, double-blind, randomized, placebo-controlled, cross-over trial. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03928496
Study type	Interventional
Source	VA Greater Los Angeles Healthcare System
Contact
Status	Completed
Phase	Phase 4
Start date	August 1, 2013
Completion date	February 2, 2017

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