Methadone in Post-Herpetic Neuralgia Pain

Post-herpetic Neuralgia Clinical Trial

— NPH  

Official title:

Methadone in Post-Herpetic Neuralgia Pain

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01752699
• Other study ID #: NPH
• Status: Completed
• Phase: Phase 3
• First received: December 11, 2012
• Last updated: March 14, 2013
• Start date: January 1998
• Est. completion date: March 2013

Study information

• Verified date: March 2013
• Source: University of Sao Paulo
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Neuropathic pain is a common condition and affecting 40 to 70% of the general population. Post-herpetic neuralgia is a condition almost complex and requires a multi modal treatment. Aim: This is a pilot proof-of-principle study designed to evaluate the use of low-dose methadone in post-herpetic neuralgia patients who remained refractory after first and second line treatment for post-herpetic neuralgia (PHN) and had indication for the association of an opioid agent to their current drug regimen.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: March 2013
• Est. primary completion date: February 2013
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients with chronic (>6 months) symptomatic PHN

• with visual analogical scale >40/100mm

• use of first and second line drugs (tricyclic antidepressants, venlafaxine and gabapentinoids)

Exclusion Criteria:

• Don't full the criteria above

Related Conditions & MeSH terms

• Neuralgia
• Neuralgia, Postherpetic
• Post-herpetic Neuralgia

Intervention

Drug:
• Methadone
patients with post-herpetic neuralgia take methadone or placebo to treat pain symptoms.
• Placebo
patients with post-herpetic neuralgia take placebo to treat the pain symptoms.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Sao Paulo

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in baseline Pain	Assessing by verbal analog scale (VAS)	baseline (visit inclusion) and three moths latter