Clinical Trials Logo

Clinical Trial Summary

Evolution of pain and neural injury will be evaluated at 2 years or longer after the onset of AHZ by multiple measures. Assessments at 2 years or longer will be compared to those collected during the first 6 months after HZ in order to test whether or not sensory function and cutaneous innervation continues to normalize beyond 6 months in subjects who recover from HZ without severe PHN.


Clinical Trial Description

Pain, nerve trunk inflammation, and neuronal injury are hallmarks of acute herpes zoster (AHZ). We hypothesize that the development of post-herpetic neuralgia (PHN) strongly depends on two factors: 1) the severity of the initial neural injury and 2) the ability to recover from the initial neural injury. To test this hypothesis, we will prospectively follow 150 patients at high risk for development of PHN. Evolution of pain and neural injury will be evaluated at 2-6 weeks, 6 weeks, 3 months, 6 months and at 2 years or longer after the onset of AHZ by multiple measures. Assessments at 2 years or longer will be compared to those collected during the first 6 months after HZ in order to test whether or not sensory function and cutaneous innervation continues to normalize beyond 6 months in subjects who recover from HZ without severe PHN. Preliminary analysis of study data showed reduced innervation in HZ skin, mirror image skin and distant control skin in the acute phase of HZ that was not specific to the persistence of pain at 3 months. The innervation appeared to recover more fully by 6 months in distant control skin than in mirror-image skin and HZ skin, despite the fact that the subjects were continuing to experience a further reduction in their zoster-associated pain. This suggests that the symptoms of pain and sensory dysfunction are not due to a mere loss in overall innervation density. The proposed subsequent ≥ 2 year study visit and analysis will allow us to directly correlate pain resolution with resolution of sensory and innervation abnormalities. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT00305357
Study type Observational
Source University of California, San Francisco
Contact
Status Completed
Phase
Start date November 2001
Completion date December 2006

See also
  Status Clinical Trial Phase
Completed NCT01944150 - Association of Transcutaneous Electrical Nerve Stimulation and Hypnosis N/A
Completed NCT00159666 - Study of Pregabalin Therapy for Pain Relief in Subjects With Post-Herpetic Neuralgia Phase 4
Not yet recruiting NCT03120962 - Effect of Early Use of Oxycodone During the Acute Phase of Herpes Zoster on Preventing Postherpetic Neuralgia N/A
Completed NCT02701374 - Efficacy and Safety of TRK-700 in Patient With Post-Herpetic Neuralgia Phase 2
Terminated NCT03094195 - Dose Response Study of EMA401 in Patients With Post-herpetic Neuralgia (PHN) Phase 2
Completed NCT02318719 - DS-5565 Phase III Study for Post-herpetic Neuralgia N/A
Completed NCT01752699 - Methadone in Post-Herpetic Neuralgia Pain Phase 3
Completed NCT01250561 - Reduction of Postherpetic Neuralgia in Herpes Zoster N/A
Completed NCT02607280 - DS-5565 Phase III Study for Renal Impairment in Japanese Subjects Phase 3
Completed NCT01037088 - Effects of Vaporized Marijuana on Neuropathic Pain Phase 1/Phase 2
Completed NCT02633306 - Transcranial Magnetic Stimulation for Facial Pain N/A
Recruiting NCT05593237 - Transcranial Magnetic Stimulation for Chronic Neuropathic Pain N/A
Completed NCT01848730 - Efficacy and Safety of CNV2197944 Versus Placebo in Patients With Post-herpetic Neuralgia Phase 2