Rectal Indomethacin in the Prevention of Post-endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis in High Risk Patients

Post-ERCP Pancreatitis Clinical Trial

Official title:
A Prospective, Randomized, Controlled Trial of Rectal Indomethacin in the Prevention of Post-ERCP Pancreatitis in High Risk Patients.

Status Terminated

Clinical Trial Summary

Pancreatitis (inflammation of the pancreas) is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP), a procedure for the diagnosis and treatment of disorders of the pancreas and bile duct.

Preliminary data has shown that non-steroidal antiinflammatory drugs, when administered rectally, can reduce the risk of pancreatitis after ERCP. This study is intended to definitively determine whether rectally administered indomethacin (a non-steroidal antiinflammatory drug)is effective at preventing pancreatitis after ERCP.

Clinical Trial Description

This study is a multi-center, randomized, placebo-controlled, double-blinded clinical trial of rectal indomethacin in the prevention of post-ERCP pancreatitis in high risk patients. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00820612
Study type	Interventional
Source	University of Michigan
Contact
Status	Terminated
Phase	Phase 4
Start date	January 2009
Completion date	July 2011

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02476279` - Stent vs. Indomethacin for Preventing Post-ERCP Pancreatitis	Phase 3
Unknown status	`NCT01771419` - Comparison Of Loop-Tip Wire Vs Tradictional Technique In The Cannulation Of The Common Bile Duct	N/A
Completed	`NCT04876768` - Effects of High FIO2 on Post-ERCP Pancreatitis.	N/A
Not yet recruiting	`NCT06250803` - Early Pancreatic Stent Placement for Preventing PEP	N/A
Completed	`NCT01912716` - Rectal Indomethacin in the Prevention of Post-ERCP Pancreatitis	Phase 2/Phase 3
Recruiting	`NCT04750044` - Refeeding in Post-ERCP Pancreatitis	N/A
Completed	`NCT03643900` - The Efficacy of Pancreatic Duct Stenting With Rectal Indomethacin in Preventing Post-ERCP Pancreatitis	N/A
Terminated	`NCT03749590` - Magnesium Sulfate in the Prevention of Post-ERCP Pancreatitis.	Phase 3
Recruiting	`NCT03708458` - Pharmacological Prophylaxis of Post- Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis	Phase 4