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Post-Bariatric Hypoglycemia clinical trials

View clinical trials related to Post-Bariatric Hypoglycemia.

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NCT ID: NCT05928390 Recruiting - Clinical trials for Post-Bariatric Hypoglycemia

Pasireotide s.c. in Patients With Post-Bariatric Hypoglycaemia

PASIPHY
Start date: January 4, 2024
Phase: Phase 2
Study type: Interventional

The Total duration of trial participation for each participant with post-bariatric hypoglycemia will be a maximum of 59 weeks, with the following duration of trial periods - 19 weeks for the Core Phase. It is composed of: - a Screening period: a maximum of 3 weeks - a Run-in period (no treatment): 4 weeks - a Blinded Treatment Phase: 12 weeks - 36 weeks Extension Phase = an open-label Treatment period - 4 weeks for the safety follow-up period (without any treatment).

NCT ID: NCT05560789 Completed - Physical Activity Clinical Trials

The Effect of Physical Activity in Individuals With Post-bariatric Hypoglycemia

Start date: January 3, 2023
Phase: N/A
Study type: Interventional

The goal of this pilot study is to evaluate the magnitude of changes in glucose and hormone levels in response to structured exercise in the fasting state in individuals with post-bariatric hypoglycemia (PBH). This pilot study will assess the adequacy of a protocol to test the following hypotheses: (1) hypoglycemia will develop in individuals with PBH in response to exercise; (2) counterregulatory hormonal responses to hypoglycemia during exercise are impaired in individuals with PBH.

NCT ID: NCT04615546 Recruiting - Clinical trials for Post-Bariatric Hypoglycemia

Role of Nutrient Transit in Hyperinsulinemic Hypoglycemia

Start date: May 6, 2020
Phase: N/A
Study type: Interventional

Severe hypoglycemia (low blood sugar)after gastric bypass surgery is an increasingly recognized condition, characterized by symptoms of hypoglycemia after eating and inappropriately elevated insulin concentrations that occur at the time of hypoglycemia. Severe hypoglycemia can be dangerous and debilitating and can also impact cognitive function. At the moment no medical therapies have been developed for this disorder. Determining why some but not other patients develop this condition would allow for improved prediction, prevention, and treatment approaches. The purpose of the study is to understand the physiological changes observed in those patients who undergo gastric bypass and develop symptomatic hypoglycemia.

NCT ID: NCT03255629 Completed - Clinical trials for Post-bariatric Hypoglycemia

Closed-Loop Glucagon Pump for Treatment of Post-Bariatric Hypoglycemia

Start date: September 19, 2017
Phase: Phase 1/Phase 2
Study type: Interventional

To assess the efficacy of a closed loop glucagon system to prevent and treat hypoglycemia occurring in patients with Post-Bariatric Hypoglycemia (PBH) in response to meals and exercise.

NCT ID: NCT02771574 Completed - Clinical trials for Post Bariatric Hypoglycemia

Efficacy, Tolerability and Pharmacokinetics of Subcutaneous Exendin (9-39) in Patients With Post Bariatric Hypoglycemia

Start date: May 2016
Phase: Phase 2
Study type: Interventional

This study is designed to evaluate the efficacy, safety and pharmacokinetics of subcutaneous exendin (9-39) in subjects with post-bariatric hypoglycemia. Development of this subcutaneous formulation of exendin (9-39) would represent a targeted therapeutic approach for this rare disease with unmet clinical need.