Post-Abortion Clinical Trial
Official title:
Oxytocin Receptor Expression in Pregnancy: When Does it Turn on
Verified date | March 2024 |
Source | Oregon Health and Science University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
This study aims to determine when during gestation oxytocin receptor (OXTR) expression increases in the myometrium, which will contribute new insight to the management of obstetric hemorrhage and our understanding of normal and abnormal labor.
Status | Active, not recruiting |
Enrollment | 30 |
Est. completion date | December 2024 |
Est. primary completion date | August 22, 2020 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 50 Years |
Eligibility | Inclusion Criteria: - Women age 18-50 - Gestational age 14-26 weeks; or 6-13 weeks, 37-42 weeks, or non-pregnant (controls) - Undergoing another planned surgical procedure with anesthesia (suction D&C, D&E, gravid hysterectomy, cesarean section, or laparoscopic tubal ligation) - Able to give informed consent in English or Spanish Exclusion Criteria: To optimize biopsy safety, we will exclude patients with anticipated difficult cases, that have additional risks of hemorrhage, or those with features that limit ultrasound visualization. Increased risk of hemorrhage: - Anemia (Hgb < 9) - Anticoagulation, bleeding disorder, or coagulopathy - Multiple gestation - Infection or sepsis For ultrasound-guided procedures: - Obese, BMI = 40 - History of =2 cesarean sections - Large fibroids or uterine anomalies obstructing view - Other poor visualization - Thin myometrium < 1cm |
Country | Name | City | State |
---|---|---|---|
United States | Oregon Health & Science University | Portland | Oregon |
Lead Sponsor | Collaborator |
---|---|
Oregon Health and Science University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Oxytocin receptor expression | Measure of oxytocin receptor expression. Perform quantitative RT-PCR on mRNA extracted from biopsy samples obtained from subjects at the end of their procedure (within 30 minutes). | 30 minutes | |
Secondary | Function of myometrial oxytocin receptor | Assessment of the function of the myometrial oxytocin receptor. Measure intracellular calcium in cultured myometrial cells after activating the receptor with oxytocin from biopsy samples obtained from subjects at the end of their procedure (within 30 minutes). | 30 minutes |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
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N/A |