PONV Clinical Trial
Official title:
Prophylactic Antiemetic Efficacy of Palonosetron Versus Ondansetron for Cesarean Sections Under Regional Anesthesia: Study Single Center, Prospective, Double-blind, Randomized, Placebo Controlled
This study aims to compare the quality of perioperative antiemesis of palonosetron and ondansetron in patients undergoing cesarean section
Perioperative nausea and vomiting (PONV) related to spinal block anesthesia are common
events and unpleasant for pregnant women. Its incidence can reach 80% in high-risk patients,
and remains high despite the emergence of new antiemetic drugs.
Episodes untreated can result in prolonged stay in post-anesthetic care unit (PACU) and
rehospitalization which can result in significant increase in overall costs of health care.
The purpose of the prophylaxis of PONV is therefore decrease its incidence, the stress of
the patient, improve the quality and safety of surgical procedure and reduce hospital costs.
Antagonists of the 5-hydroxytryptamine 3 subtype receptor have been widely used and
effective against PONV due to its efficacy and a favorable side-effect profile. Palonosetron
is a new and potent drug generation5 second-HT antagonist with improved profile that acts
longer. Recent studies where it was compared to ondansetron and palonosetron in high-risk
patients in head and neck surgery and laparoscopic surgery is disclosed palonosetron far
superior to ondansetron especially 2-24 hours after surgery. But there are no studies on
caesareans comparing the two drugs.
This prospective, randomized, double-blind, placebo controlled, was designed to evaluate the
efficacy of palonosetron compared with ondansetron and placebo for the prevention of nausea
and vomiting in patients undergoing cesarean delivery under spinal anesthesia.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT01945502 -
Nasopharyngeal Packing and Rhinologic Surgery.
|
N/A | |
Completed |
NCT01840254 -
Effect of Combination Dexmedetomidine Added to Fentanyl-based Intravenous Patient-controlled Analgesia on Nausea Vomiting in Highly Susceptible Patients Undergoing Lumbar Spinal Surgery: Prospective Double Blinded Randomized Controlled Trial
|
N/A | |
Completed |
NCT00772226 -
The Use of Music as Pain Therapy in Patients Undergoing Laparoscopic Cholecystectomy in a Day Care Unit
|
Phase 3 | |
Completed |
NCT00760253 -
Compare the Side Effects and Difference Awake Level of Three TCI Propofol Formula in TVOR Patients
|
N/A | |
Recruiting |
NCT03783182 -
Betamethasone (Betapred®) as Premedication for Reducing Postoperative Vomiting and Pain After Tonsillectomy
|
Phase 4 | |
Recruiting |
NCT03835234 -
Incidence and Factors Associated With PONV in Regional Anaesthesia
|
||
Recruiting |
NCT04191694 -
Chewing Gum to Prevent Nausea and Vomiting After Caesarean Section Under Spinal Anaesthesia
|
N/A | |
Recruiting |
NCT05596695 -
Minimisation of Blood Pressure Variability and Postoperative Nausea and Vomiting
|
N/A | |
Recruiting |
NCT04570592 -
Granisetron vs Granisetron and Dexamethasone on the Reduction of Postoperative Nausea and Vomiting
|
Phase 2 | |
Completed |
NCT02116257 -
The Opioid-sparing Effect and Reduced PONV Using Propacetamol in PCA Among Patients With High Risk of PONV
|
N/A | |
Not yet recruiting |
NCT05396716 -
Acupoint Stimulation Alleviates Postoperative Nausea and Vomiting
|
N/A | |
Active, not recruiting |
NCT00892996 -
Efficacy of Prevention for Postoperative Nausea and Vomiting After Intrathecal Morphine in Cesarean Section
|
N/A | |
Recruiting |
NCT04866121 -
Acupuncture for Prevention of Postoperative Nausea and Vomiting
|
N/A | |
Completed |
NCT02809378 -
The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of PONV
|
Phase 4 | |
Completed |
NCT05408676 -
Comparison of Dexamethasone Alone vs in Combination With Pericardium 6 (P6) Electrical Stimulation or Granisetron in the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Breast Cancer Surgery
|
N/A | |
Completed |
NCT01991821 -
European Phase III Study of APD421 in PONV
|
Phase 3 | |
Completed |
NCT00952133 -
Efficacy of IV Palo With IV Dexamethasone vs IV Palo for Prevention of Immediate & Delayed PONV
|
Phase 4 | |
Completed |
NCT04054479 -
Penehyclidine for PONV Prophylaxis After Strabismus Surgery
|
Phase 4 | |
Completed |
NCT05540236 -
Effects of Auricular Acupressure on the Management of Postoperative Nausea and Vomiting After Gynecological Laparoscopic Surgeries
|
N/A | |
Completed |
NCT03278522 -
Ramosetron Pre-treatment for PONV and QT Prolongation
|
Phase 4 |