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Spectrum of Peripheral and Autonomic Neuropathies in Patients With aTTRwt Amyloidosis and Response to Patisiran Therapy

Transthyretin Amyloidosis Clinical Trial

Official title:
Spectrum of Peripheral and Autonomic Neuropathies in Patients With aTTRwt Amyloidosis and Response to Patisiran Therapy

Clinical Trial Summary

To evaluate the efficacy and safety of patisiran in patients with wtATTR amyloidosis and symptomatic polyneuropathy by evaluating the effect on neurologic impairment and quality of life.

Clinical Trial Description

The study will consist of a baseline screening period and a 24-month treatment period. Eligible patient will receive patisiran administered as an IV infusion once every 21 days for a 24-month period. During the 24-month treatment period study patients will undergo assessments for efficacy and/or safety as outlined in the schedule of assessments with key efficacy assessments being performed prior to the first dose and proceeding as outlined in the schedule of assessments. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05023889
Study type Interventional
Source Austin Neuromuscular Center
Contact Yessar Hussain, MD
Phone 5129200140
Email yessar@austinneuromuscle.com
Status Recruiting
Phase Early Phase 1
Start date August 3, 2022
Completion date December 2024
View Details
See also
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