Giant Cell Arteritis Clinical Trial
Official title:
Polymyalgia Rheumatica and Giant Cell Arteritis - Three Challenges - Consequences of the Vasculitis Process, Osteoporosis and Malignancy: A Prospective Cohort Study Protocol
The purpose of this study is to delineate the association of the 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) detected vasculitis pattern of the large vessels (PET positivity) and the clinical picture of Polymyalgia Rheumatica (PMR)/Giant Cell Arteritis (GCA) .
Introduction:
Polymyalgia Rheumatica (PMR) and Giant Cell Arteritis (GCA) are common inflammatory
conditions. The diagnosis of PMR/GCA poses many challenges since there are no specific
diagnostic tests. Recent literature emphasizes the ability of 18F-Fluorodeoxyglucose
Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) to assess global disease
activity and/or inflammation burden. 18F-FDG PET/CT may lead to make diagnosis at an earlier
stage than conventional imaging and assess response to therapy. With respect to the
management of PMR/GCA, there are three significant areas of concern as follows: Vasculitis
process/vascular stiffness, malignancy and osteoporosis.
Methods and Analysis:
Patients: All patients with the suspicion of PMR/GCR will be offered to participate in the
study. The current protocol consists of 4 separate studies including: I) The association of
clinical picture of PMR/GCA with PET detected vasculitis II) Evaluating validity of 18F-FDG
PET/CT scan for diagnosis of PMR/GCA compared to temporal artery biopsy III) Incidence of
new diagnosed malignancies in patients with PMR/GCA, or PMR like syndrome with the aim of
PET/CT scan and Chest X ray/Abdominal ultrasound IV) Impact of disease process as well as
steroid treatment on bone mineral density, body composition and vasculitis/vascular
stiffness in PMR/GCA patients.
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