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Clinical Trial Summary

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is an autosomal recessive disease caused by mutations in the autoimmune regulator (AIRE) gene, characterized by the clinical triad of chronic mucocutaneous candidiasis (CMC), hypoparathyroidism, and adrenal insufficiency. CMC can be complicated by systemic candidiasis or oral squamous cell carcinomas (SCCs) and may lead to death. The role of chronic Candida infection in the etiopathogenesis of oral SCC is unclear. Long term use of fluconazole lead to emergence of C. albicans strains with azoles decreased susceptibility. CMC is associated with an impaired Th17 cell response, however, it remains unclear whether decreased serum IL-17 and IL-22 levels are related to a defect in cytokine production or to neutralizing autoantibodies resulting from mutations in the AIRE gene


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03800056
Study type Observational
Source University Hospital, Lille
Contact Marie-Christine VANTYGHEM, MD,PhD
Phone 320 44 45 17
Email mc-vantyghem@chru-lille.fr
Status Recruiting
Phase
Start date April 23, 2021
Completion date April 2026

See also
  Status Clinical Trial Phase
Completed NCT02421276 - Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome N/A