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Clinical Trial Summary

The trial will be a phase III, randomised-controlled, multi-centre, international, open-label trial consisting of ruxolitinib versus best available therapy, where best available therapy is a choice of interferon alpha, any formulation permitted (IFN) or hydroxycarbamide (HC), and which will be elected by the Investigator prior to randomisation.


Clinical Trial Description

The trial will be a phase III, randomised-controlled, multi-centre, international, open-label trial consisting of ruxolitinib versus best available therapy, where best available therapy is a choice of interferon alpha, any formulation permitted (IFN) or hydroxycarbamide (HC), and which will be elected by the Investigator prior to randomisation. There will be no cross-over either between arm A and B or between therapies on Arm B HC and IFN will be provided as best available therapy, IFN can include standard of pegylated-interferon at Investigators discretion. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04116502
Study type Interventional
Source University of Birmingham
Contact Alex Hainsworth
Phone +44(0)121 414 2535
Email mithridate@trials.bham.ac.uk
Status Recruiting
Phase Phase 3
Start date October 25, 2019
Completion date February 1, 2028

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