Clinical Trials Logo

Clinical Trial Summary

Pneumothorax refers to air in the pleural cavity (i.e. interspersed between the lung and the chest wall).1 Primary spontaneous pneumothorax (PSP) mostly occurs in healthy individuals without an apparent cause, probably due to the rupture of subpleural blebs located mostly on the apex of the lung or the apical segment of the lower lobe. Compared to PSP, a secondary spontaneous pneumothorax (SSP) occurs in the setting of underlying pulmonary disease, like COPD.2 Surgical treatment involves resection of apical bleb disease and pleurodesis which could be chemical or mechanical. Mechanical pleurodesis accomplished either via pleurectomy or pleural abrasion.3 In this study, we aim to compare the efficiency and recurrence risk of pleural abrasion versus pleurectomy in patients with Spontaneous pneumothorax.


Clinical Trial Description

Pneumothorax is a relatively common clinical problem which can occur in individuals of any age. Irrespective of aetiology (primary, or secondary to lung disorders or injury), immediate management depends on the extent of cardiorespiratory impairment, degree of symptoms and size of pneumothorax. 4 The presentation of a pneumothorax varies between minimal pleuritic chest discomfort and breathlessness to a life threatening medical emergency with cardiorespiratory collapse requiring immediate intervention.5-7 Typical signs include reduced breath sounds, reduced ipsilateral chest expansion and hyper resonant percussion note. Mediastinal shift away from the affected side, tachycardia, tachypnea and hypotension occur in Tension pneumothorax. 8 Pneumothorax can be categorized as spontaneous which maybe primary or secondary and traumatic according to aetiology. Occasionally, individuals may develop a concomitant haemothorax due to bleeding caused by shearing of adjacent subpleural vessels when the lung collapses.4 A primary spontaneous pneumothorax (PSP) is a condition that occurs predominantly in young and thin male individuals who do not have any history of underlying lung disease. Although it is mostly attributed to the rupture of a subpleural bleb or bulla, the exact cause of PSP is still unknown.1 Moreover, current cigarette smoking greatly increases the risk of developing PSP by as much as nine times, with evidence of a dose-response relationship.9 Secondary spontaneous pneumothorax (SSP) frequently occurs in association with primary diseases, such as chronic obstructive pulmonary disease (COPD), interstitial pneumonia (IP), and pulmonary fibrosis disease (PFD). 10 Treatment of spontaneous pneumothorax depends on the patient's condition and can range from conservative treatment, drainage, and pleurodesis, to surgical treatment.10 Surgical treatment is based on resection of bullous lesions causing air leakage and techniques to prevent recurrence. Surgical treatment without additional pleurodesis may increase the risk of recurrence, Various pleurodesis techniques such as chemical pleurodesis or mechanical pleurodesis via pleural abrasion or pleurectomy are used to reduce the recurrence rate.1 ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05407974
Study type Interventional
Source Ain Shams University
Contact Abdelfatah E Abugabal
Phone +201098064416
Email abdelfatah_abugabal@hotmail.com
Status Recruiting
Phase N/A
Start date October 3, 2021
Completion date May 1, 2023

See also
  Status Clinical Trial Phase
Recruiting NCT06022081 - Lung Ultrasound Versus Chest Radiography for Detection of Pneumothorax N/A
Recruiting NCT02907866 - Use of Endobronchial Ultrasound Scope (EBUS) Transducer to Identify Pneumothorax-A Feasibility Study
Terminated NCT03034421 - Prevention of Pneumothorax Following Endoscopic Valve Therapy in Patients With Severe Emphysema N/A
Completed NCT02232841 - Electrical Impedance Imaging of Patients on Mechanical Ventilation N/A
Completed NCT02619591 - Comparison Of Chest Ultrasound Techniques To Identify Clinically Significant Pneumothorax N/A
Recruiting NCT05342675 - Effect of Rapid Rollover on Pneumothorax After CT-Guided Lung Biopsy N/A
Recruiting NCT05910112 - Prospective Data Collection on Clinical, Radiological and Patient Reported Outcomes After Pleural Intervention
Completed NCT03656406 - Effect of Lateral Positioning on Bronchial Cuff Pressure of Left-sided Double-lumen Endotracheal Tube During Thoracic Surgery
Active, not recruiting NCT06075836 - AI Assisted Detection of Chest X-Rays
Recruiting NCT03728491 - Education and Training Competences in Thoracic Ultrasound N/A
Completed NCT01670942 - Hypobaria and Traumatic Pneumothorax N/A
Terminated NCT00969423 - Chronic Pain After Video-assisted Thoracoscopic Surgery (VATS) Surgery for Pneumothorax N/A
Completed NCT05904574 - Effectiveness of the Autologous Blood Patch Method in Lung Biopsies
Completed NCT03327688 - Point-of-care Ultrasound in Finland N/A
Completed NCT05963945 - Multi-Reader Retrospective Study Examining Carebot AI CXR 2.0.21-v2.01 Implementation in Everyday Radiology Clinical Practice
Completed NCT05222568 - Effect of the Minimum Bronchial Cuff Volume of Left-sided Double-lumen Endotracheal Tube for One-lung Ventilation on the Change of the Bronchial Cuff Pressure During Lateral Positioning in Thoracic Surgery
Not yet recruiting NCT05121233 - Local Anesthesia Versus Combined Local Anesthesia With Single Dose Analgesia on Pain Control During Thoracic Ultrasound Guided Procedures Phase 4
Completed NCT03064659 - Driving Pressure And EFL in Adult Cardiac Surgery N/A
Recruiting NCT02090205 - Mechanical Ventilation During Cardiac Surgery N/A
Active, not recruiting NCT01855464 - Wedge Resection or Parietal Pleurectomy for the Treatment of Recurrent Pneumothorax (WOPP) N/A