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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT01135004
Other study ID # 200912060R
Secondary ID
Status Recruiting
Phase N/A
First received May 30, 2010
Last updated June 1, 2010
Start date March 2010
Est. completion date February 2013

Study information

Verified date March 2010
Source National Taiwan University Hospital
Contact Jin-Shing Chen, MD, PhD
Phone 886-2-23123456
Email chenjs@ntu.edu.tw
Is FDA regulated No
Health authority Taiwan: Department of Health
Study type Observational

Clinical Trial Summary

Primary spontaneous pneumothorax most commonly occurs in young, tall, lean males. The estimated recurrence rate is 23-50% after the first episode and increases to 60% after the second pneumothorax. The pathogenesis of this benign disease remains unclear. Generally, rupture of the emphysematous change or blebs in the apex of the lung is considered as the cause of pneumothorax. The main purpose of this study is to investigate the molecular pathogenesis of blebs formation or emphysematous change of the lung in these young, healthy patients.


Description:

Primary spontaneous pneumothorax most commonly occurs in young, tall, lean males. The estimated recurrence rate is 23-50% after the first episode and increases to 60% after the second pneumothorax. The pathogenesis of this benign disease remains unclear. Generally, rupture of the emphysematous change or blebs in the apex of the lung is considered as the cause of pneumothorax. The main purpose of this study is to investigate the molecular pathogenesis of blebs formation or emphysematous change of the lung in these young, healthy patients. The blebs resected from the pneumothorax patients will be used for RNA and protein levels analyses. The adjacent normal lung tissue will be used as a control for comparison.


Recruitment information / eligibility

Status Recruiting
Enrollment 30
Est. completion date February 2013
Est. primary completion date February 2012
Accepts healthy volunteers No
Gender Both
Age group 14 Years to 40 Years
Eligibility Inclusion Criteria:

- Age between 14 and 40 years

- Spontaneous pneumothorax

- Underwent bullectomy of the lung

Exclusion Criteria:

- With underlying lung disease

Study Design

Observational Model: Cohort, Time Perspective: Prospective


Related Conditions & MeSH terms


Intervention

Procedure:
Thoracoscopic bullectomy
Thoracoscopic wedge resection of the diseased lung

Locations

Country Name City State
Taiwan National Taiwan University Hospital Taipei

Sponsors (3)

Lead Sponsor Collaborator
National Taiwan University Hospital National Science Council, Taiwan, National Taiwan University Hospital, Yun-Lin Branch

Country where clinical trial is conducted

Taiwan, 

References & Publications (1)

Ayed AK, Chandrasekaran C, Sukumar M. Video-assisted thoracoscopic surgery for primary spontaneous pneumothorax: clinicopathological correlation. Eur J Cardiothorac Surg. 2006 Feb;29(2):221-5. Epub 2005 Dec 20. — View Citation

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