Pathogenesis of Primary Spontaneous Pneumothorax

Pneumothorax Clinical Trial

Official title: Molecular Pathogenesis of Primary Spontaneous Pneumothorax

Status Recruiting

Clinical Trial Summary

Primary spontaneous pneumothorax most commonly occurs in young, tall, lean males. The estimated recurrence rate is 23-50% after the first episode and increases to 60% after the second pneumothorax. The pathogenesis of this benign disease remains unclear. Generally, rupture of the emphysematous change or blebs in the apex of the lung is considered as the cause of pneumothorax. The main purpose of this study is to investigate the molecular pathogenesis of blebs formation or emphysematous change of the lung in these young, healthy patients.

Clinical Trial Description

Primary spontaneous pneumothorax most commonly occurs in young, tall, lean males. The estimated recurrence rate is 23-50% after the first episode and increases to 60% after the second pneumothorax. The pathogenesis of this benign disease remains unclear. Generally, rupture of the emphysematous change or blebs in the apex of the lung is considered as the cause of pneumothorax. The main purpose of this study is to investigate the molecular pathogenesis of blebs formation or emphysematous change of the lung in these young, healthy patients. The blebs resected from the pneumothorax patients will be used for RNA and protein levels analyses. The adjacent normal lung tissue will be used as a control for comparison. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Pneumothorax

• NCT number: NCT01135004
• Study type: Observational
• Source: National Taiwan University Hospital
• Contact: Jin-Shing Chen, MD, PhD
• Phone: 886-2-23123456
• Email: chenjs@ntu.edu.tw
• Status: Recruiting
• Phase: N/A
• Start date: March 2010
• Completion date: February 2013