Moderate vs Deep Neuromuscular Block on Biotrauma During Laparoscopy

Status Completed

Clinical Trial Summary

The purposes of this study is to investigate the effects of moderate vs. deep neuromuscular block on respiratory mechanics and biotrauma in patients with intraoperative protective lung ventilation for laparoscopy.

Clinical Trial Description

Mechanical ventilation results in the disruption of the alveolar-capillary barrier and increased permeability, a hallmark of experimental ventilator-induced lung injury. These mechanical forces also induce an increase in the concentrations of inflammatory cytokines.

The benefits of deep neuromuscular blocks for laparoscopic procedures are controversial and most of the studies undertaken have only sought to improve surgical conditions. Theoretically, deep neuromuscular block permits a lower abdominal insufflation pressure, which leads to better respiratory mechanics and gas exchange. The investigators examined the effects of moderate vs. deep neuromuscular block on respiratory mechanics and biotrauma in patients with intraoperative protective lung ventilation for laparoscopy. The investigators hypothesized that deep neuromuscular block (PTC 1 or 2) and low pressure pneumoperitoneum (8 mmHg) would improve respiratory mechanics and reduce inflammatory processes associated with biotrama during mechanical ventilation compared with moderate neuromuscular block (TOF count 1 or 2 ) and standard pressure pneumoperitoneum (12-15 mmHg). ;

Study Design

Related Conditions & MeSH terms

Pneumoperitoneum

Clinical Trial Details

NCT number	NCT03576118
Study type	Interventional
Source	Ajou University School of Medicine
Contact
Status	Completed
Phase	N/A
Start date	November 5, 2018
Completion date	September 19, 2019

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT06075836` - AI Assisted Detection of Chest X-Rays
Completed	`NCT03572413` - The Effect of Low Pressure Pneumoperitoneum During Laparoscopic Colorectal Surgery on Innate Immune Homeostasis.	Phase 4
Completed	`NCT03608436` - The Effect of Low Pressure Pneumoperitoneum During Laparoscopic Colorectal Surgery on Early Quality of Recovery	Phase 4
Completed	`NCT04146090` - Low-pressure vs Standard-pressure in Laparoscopic Cholecystectomy	N/A
Completed	`NCT02853591` - Comparison of Pneumoinsufflation Modes and Pressure Settings in Gynecology	N/A
Completed	`NCT02079337` - Validation of Subjective Rating Scales Used to Assess Surgical Conditions in Abdominal Surgery	Phase 4
Completed	`NCT01512511` - Comparing Nitrous Oxide and Carbon Dioxide for Laparoscopic Cholecystectomy	N/A
Not yet recruiting	`NCT06116383` - Evaluation of Renal Perfusion With NIRS in Laparoscopic Surgery
Withdrawn	`NCT03933254` - Intraocular Pressure and Optic Nerve Sheath Diameter Changes in Laparoscopic Cholecystectomies
Recruiting	`NCT03069586` - Effect Low Pressure Pneumoperitoneum and Pulmonary Recruitment on Postoperative Pain	N/A
Recruiting	`NCT01867814` - Arterial and Plethysmographic Waveforms Variables as Predictors of Hemodynamic Response to Pneumoperitoneum	N/A
Terminated	`NCT01854307` - The Influence of Pneumoperitoneum on Minimal Invasive Cardiac Output Measurements	N/A
Recruiting	`NCT06447545` - Comparison Between Low Pressure Pneumoperitoneum With High Pressure Pneumoperitoneum in Post-operative Pain, Shoulder Tip Pain and Common Bile Duct Injuries in Patients Undergoing Laparoscopic Cholecystectomy	N/A
Completed	`NCT05992636` - Different Insufflation Flows and Effects on Cerebral Oxygenation in Laparoscopic Cholecystectomy
Completed	`NCT03957837` - Optical Nerve Sheath Changes During Head Down Laparoscopy
Recruiting	`NCT06319053` - The Turbine-based Insufflator Safety and Feasibility Study	N/A
Completed	`NCT04125173` - Effect of Lower Pneumoperitoneum Pressure During Laparoscopic and Robotic Hysterectomy	N/A
Not yet recruiting	`NCT02690688` - Intra-abdominal Pressure and Dynamic Preload Variables	N/A
Completed	`NCT05238506` - Lidocaine VS Hemodynamic, Metabolic and Hormonal Response	Phase 4
Completed	`NCT03928171` - The Effect of Intra-abdominal Pressure on Peritoneal Perfusion During Laparoscopic Colorectal Surgery	N/A