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Study Comparing Inhaled Amikacin Versus Placebo to Prevent Ventilator Associated Pneumonia — AMIKINHAL  

Pneumonia, Ventilator-Associated Clinical Trial

Official title:
Double-blinded Multicenter Randomized Controlled Trial Comparing Inhaled Amikacin Versus Placebo to Prevent Ventilator Associated Pneumonia

Clinical Trial Summary

The objective of the study is to prove that after the third day of invasive mechanical ventilation a three-day course of inhaled amikacin reduces the incidence of subsequent VAP. Parallel two group double blind randomized controlled clinical trial. Individual randomization, performed on day 4 of invasive mechanical ventilation, will be stratified on centre in order to account for variations in VAP prevention bundle implementation and use of systemic antibiotics the day of randomization. Patients will be treated three consecutive days with inhaled amikacin or placebo. Patients will be followed up daily in the intensive care unit for the occurrence of VAP according to international guidelines until day 28.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03149640
Study type Interventional
Source University Hospital, Tours
Contact
Status Completed
Phase Phase 3
Start date July 19, 2017
Completion date June 17, 2021
View Details
See also
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