Pneumonia, Ventilator-Associated Clinical Trial
Official title:
Etude INCIPAVE: INCidence Des Pneumopathies Acquises Sous Ventilation Chez l'Enfant
Rationale : ventilator associated pneumonia (VAP) has been extensively studied in adults,
however, few data exist regarding VAP in the paediatric intensive care population. The
Centers for Disease Control (CDC) definition for VAP is regularly updated trying to
homogenised practice, and the last version for paediatrics has been published in 2015.
According to the latest CDC definition, the investigators aim to study incidence of VAP in
different paediatric intensive care units (PICUs), diagnostic methods of identifying VAP,
microbiology of VAP, and utilisation of empirical antimicrobial therapy.
Methods and population : a prospective multicentre observational study will be conducted in
European PICUs for one year. All patients admitted to PICU aged more than 28 days and < 18
years, mechanically ventilated either by endotracheal or tracheostomy tube are included.
Clinical data, ventilation settings, and risk factors for VAP are inserted daily in an
electronic database on the internet. The investigators are going to identify patients, who
presented one or more episodes of VAP during PICUs stay, analysing onset circumstances,
diagnostic methods, bacteria pathogens identified, and antibiotic treatment. VAP incidence
will be reported as number of events per 1,000 ventilator-days. Risk factors associated to
VAP will be identified by univariate and multivariate analysis.
Results and perspective : the investigators aim to define for the first time the incidence
of VAP among European PICUs with a prospective and multicentre study. The identification of
risk factors, diagnostic methods, epidemiology, treatment strategies will define the basis
to start prevention manoeuvres and improve the clinical strategies for VAP in paediatric
intensive care population.
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