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NCT00529776 Clinical Trial

Prophylaxis of Ventilator Associated Pneumonia by Continuous Lateral Rotation Therapy

Pneumonia, Ventilator-Associated Clinical Trial

Official title:
Prophylaxis of Ventilator Associated Pneumonia by Continuous Lateral Rotation Therapy

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00529776
Other study ID # EK 38/2004
Secondary ID
Status Completed
Phase N/A
First received September 12, 2007
Last updated June 10, 2008
Start date September 2005
Est. completion date May 2008

Study information
Verified date June 2008
Source Medical University of Vienna
Contact n/a
Is FDA regulated No
Health authority Austria: Federal Ministry for Health and Women
Study type Interventional

Clinical Trial Summary

Hypothesis: Ventilator associated pneumonia (VAP) in critically ill patients may be prevented by continuous lateral rotation therapy (CLRT) using specially designed, motor driven beds.

Patients are randomized to CLRT or supine position if mechanically ventilated and not suffering from pneumonia or ARDS within 48 hours after intubation. Prophylaxis of VAP is standardized in both groups. Primary endpoint is incidence of VAP, secondary endpoints are length of ventilation, length of stay and mortality.

Recruitment information / eligibility
Status Completed
Enrollment 150
Est. completion date May 2008
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 89 Years
Eligibility Inclusion Criteria:

- Mechanically ventilated

- Intubated not longer than 48 h

- Medical cause for ICU admission

- Expected to be ventilated for > 48 hours

Exclusion Criteria:

- Pneumonia or ARDS present

- Postoperative patient

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

Intervention

Procedure:
• Continuous lateral rotation therapy

Locations
Country Name City State
Austria Vienna General Hospital, Medical University of Vienna Vienna

Sponsors (1)
Lead Sponsor Collaborator
Medical University of Vienna

Country where clinical trial is conducted

Austria, 

Outcome
Type Measure Description Time frame Safety issue
Primary Ventilator associated pneumonia
Secondary Length of hospital stay
Secondary Length of mechanical ventilation
Secondary ICU and hospital Mortality
See also
  Status Clinical Trial Phase
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Completed NCT00521677 - Comparison Between Two Methods of Oral Care on the Incidence of VAP N/A
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Completed NCT02950519 - Endotracheal Tube Cuff Pressures in Ventilated Patients N/A
Completed NCT01875692 - Can we Better Understand the Development of VAP and Eventually Predict and Prevent it? N/A
Completed NCT00515034 - A Safety and Tolerability Study of Doripenem in Patients With Abdominal Infections or Pneumonia Phase 2
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Completed NCT01577862 - Colistin and Rifampicin for MDR-Acinetobacter Phase 3
Completed NCT00572559 - Microbiologic Response With Linezolid And Vancomycin In Ventilator-Associated Pneumonia Due To Methicillin Resistant Staphylococcus Aureus Phase 4
Withdrawn NCT04566172 - Preoperative Optimization to Improve Functional Status N/A
Recruiting NCT04215692 - Lung Ultrasound-guided Fluid Therapy in Pediatric Intensive Care Unit Patients N/A
Completed NCT03816956 - Adjunctive Therapy to Antibiotics in the Treatment of S. Aureus Ventilator-Associated Pneumonia With AR-301 Phase 3
Active, not recruiting NCT01123681 - Intubation and Extubation Over 48 Hours Mechanical Ventilation N/A
Recruiting NCT04839653 - Efficacy and Safety of Selective Digestive Decontamination in the ICU With High Rates of Antibiotic-resistant Bacteria N/A
Recruiting NCT03527992 - Automated Oxygen Administration in Patients With Hypoxemic Pneumonia and Pleuropneumonia N/A
Recruiting NCT05405491 - Impact of a Strategy Based on Bacterial DNA Detection to Optimize Antibiotics in Immunocompromised Patients With Hospital-acquired Pneumonia Requiring Mechanical Ventilation N/A