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Pneumonia, Ventilator-Associated clinical trials

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NCT ID: NCT02838160 Completed - Clinical trials for Ventilator-associated Pneumonia

Effectiveness of Different Educational Strategies on the KAP, Psychological and Clinical Outcomes

Start date: October 2011
Phase: N/A
Study type: Interventional

A randomized controlled triple blinded clinical trial with repeated measurements. The reporting of this study complies with the CONSORT (Consolidated Standards of Reporting Trials) statement for trials of non-pharmacological treatments. The first aim of the study was to evaluate the effectiveness of the three competing interventions on the critical care nurses' knowledge of, attitudes toward and adherence to 17 ventilator bundle components; the second aim was to determine the effectiveness of adherence to 17 ventilator bundle components with pre-defined ventilator bundle on the psychological factors of critical care nurses including nurses' stressors in intensive care unit (ICU), perceived stress, trait and state anxieties; the third aim was to evaluate their impact on the clinical outcomes; and the fourth aim was comparing KAP and psychological factors with clinical outcomes.

NCT ID: NCT02837835 Completed - Pneumonia Clinical Trials

Lung Concentrations of Ceftazidime in Patients With Ventilator-associated Pneumonia

CEFTALC
Start date: March 2005
Phase: Phase 3
Study type: Interventional

Ceftazidime is a beta-lactam compound that exerts a time-dependent bactericidal effect. Numerous arguments are in favor of continuous administration of ceftazidime, both for reasons of clinical efficacy and to preserve bacteriological mutation. The investigators report a prospective, single-center, parallel-group, randomized, controlled trial comparing two modes of administration of ceftazidime, namely, continuous administration (loading dose of 20 mg/kg of body weight followed by 60 mg/kg/day) versus intermittent administration (20 mg/kg over 30 min every 8 h) in 34 patients with ventilator-associated pneumonia due to Gram-negative bacilli. The study was performed over 48 h with 13 and 18 assessments of serum ceftazidime in the continuous-infusion group (group A) and the intermittent-fusion group (group B), respectively. Bronchoalveolar lavage (BAL) was performed at steady state in both groups at 44 h to determine ceftazidime levels in the epithelial lining fluid. The investigators chose a predefined threshold of 20 mg/liter for serum concentrations of ceftazidime because of ecological conditions in our center.

NCT ID: NCT02806141 Terminated - Clinical trials for Pneumonia, Ventilator-Associated

Aerosolized Plus Intravenous vs. Intravenous Colistin for VAP Due to Pandrugs-resistant A. Baumannii in Neonates

Start date: September 2016
Phase: Phase 3
Study type: Interventional

This study is planned to compare the clinical efficacy and safety of aerosolized plus intravenous colistin vs. intravenous colistin as adjunctive therapy for the treatment of ventilator-associated pneumonia (VAP) due to pandrugs-resistant (PDR) Acinetobacter baumannii in the neonates.

NCT ID: NCT02756351 Completed - Clinical trials for Pneumonia, Ventilator-Associated

A Efficacy and Safety Study of Nasal Prongs With Proprietary Surface Coating Aiming to Reduce Bacterial Colonization

Start date: April 2016
Phase: N/A
Study type: Interventional

The study is a first step in establishing the safety and efficacy of the CytaCoat technology when applied to a medical device such as a nasal prong and the clinical data generated will serve as a basis for continuous studies in clinically significant settings such as the neonatal care units.

NCT ID: NCT02753608 Completed - Clinical trials for Pneumonia, Ventilator-associated

Early Detection of Ventilator-associated Pneumonia (VAP)

cheqVAP
Start date: June 28, 2016
Phase: N/A
Study type: Interventional

The study goal consists in the sequential collection of exhaled breath condensates (EBC) from patients receiving invasive ventilation. Subsequent Raman spectroscopy aims at the identification of putative biomarkers that could enable rapid early distinction of Ventilator-associated pneumonia.

NCT ID: NCT02714595 Completed - Sepsis Clinical Trials

Study of Cefiderocol (S-649266) or Best Available Therapy for the Treatment of Severe Infections Caused by Carbapenem-resistant Gram-negative Pathogens

CREDIBLE - CR
Start date: September 7, 2016
Phase: Phase 3
Study type: Interventional

This study is designed to provide evidence of efficacy of cefiderocol in the treatment of serious infections in adult patients caused by carbapenem-resistant Gram-negative pathogens.

NCT ID: NCT02704923 Completed - Clinical trials for Ventilator-Associated Pneumonia

Atropine for Preventing Ventilator-Associated Pneumonia

Start date: February 2015
Phase: Phase 2
Study type: Interventional

A double-blind, placebo controlled trial of atropine eye drops used by sublingual way for preventing Ventilator-Associated Pneumonia.

NCT ID: NCT02689531 Completed - Clinical trials for Pneumonia, Bacterial

CTTI Risk Factors for HABP/VABP Study

PROPHETIC
Start date: February 2016
Phase:
Study type: Observational

The purpose of this study is to better define the intensive care unit population at highest risk for developing Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia (HABP/VABP).

NCT ID: NCT02683603 Completed - Clinical trials for Pneumonia, Ventilator-Associated

Effect of Aerosolised Colistin in Ventilator Associated Pneumonia

Start date: April 2013
Phase: Phase 4
Study type: Interventional

the management of Ventilator-associated pneumonia (VAP) caused by multidrug-resistant (MDR) gram-negative bacilli (GNB) represent a real therapeutic dilemma in intensive care unit (ICU). Colistin remains an effective agent against MDR GNB. However, because of its side effects, mainly nephrotoxicity, other modalities than the intra venous (IV) route should be tried. Several recent data emphasize the interest of inhaled route. The investigators purpose was to evaluate the effectiveness and systemic toxicity of aerosolized colistin in ventilator associated pneumonia.

NCT ID: NCT02683122 Completed - Clinical trials for Pneumonia, Ventilator-Associated

The DIPOD Study (Diagnosis Improvement of Pneumonia by Organ Dysfunction)

DIPOD
Start date: January 2016
Phase: N/A
Study type: Observational

The place of analysis of organ dysfunction in relation to the diagnosis of nosocomial pneumonia in intensive care is not yet defined.