Clinical Trials Logo

Pneumonia, Ventilator-Associated clinical trials

View clinical trials related to Pneumonia, Ventilator-Associated.

Filter by:

NCT ID: NCT04563104 Completed - Clinical trials for Ventilator Associated Pneumonia

Lung Ultrasound in Procalcitonin- Guided Antibiotic Discontinuation in Ventilator Associated Pneumonia

Start date: October 1, 2020
Phase:
Study type: Observational

Ventilator Associated pneumonia (VAP) is associated with longer ICU length of stay, prolonged mechanical ventilation, and increased use of antimicrobials, health-care cost and mortality . Acute respiratory infections (ARIs) comprise a large and heterogeneous group of infections, including bacterial infections, viral infections, and infections of other etiologies. Early initiation of adequate antibiotic therapy is the cornerstone in the treatment. However, overuse of antibiotics and prolonged duration of antibiotic therapy in patients with bacterial ARIs in the hospital and intensive care setting is associated with increased resistance for common bacteria, high costs, and adverse drug reactions.

NCT ID: NCT04527276 Completed - Clinical trials for Ventilator Associated Pneumonia

Reducing the Incidence of VAP in Critically Ill Children and Assessment of Oral Care With CHX

Start date: February 1, 2019
Phase: N/A
Study type: Interventional

This was a single-centered, randomized, placebo-controlled double-blind clinical trial conducted in the pediatric intensive care unit (PICU), in patients who were aged 1 month to 18 years, needing MV for at least 48 hours, to evaluate the effect of Chlorhexidine (CHX) on Ventilator-associated pneumonia (VAP) incidence and to determine VAP risk factors.

NCT ID: NCT04505202 Completed - Clinical trials for Ventilator Associated Pneumonia

Effect of Chlorhexidine-Induced Oral Care on Ventilator-Related Some Respiratory System Complications

Start date: April 15, 2019
Phase: N/A
Study type: Interventional

Ventilator-associated pneumonia and ventilator-associated treakeabronchitis in respiratory tract infections associated with ventilator are common infections in intensive care unit and cause significant morbidity, mortality and health expenditures in nosocomial infections. Adequate and effective oral care by nurses in intensive care patients, possible complications, intensive care unit stay in the intensive care unit and is very important in terms of mortality.

NCT ID: NCT04488510 Active, not recruiting - Covid19 Clinical Trials

Pathogens Involved in Secondary Infections During Severe Forms of Covid-19 Pneumonia:

COVAP
Start date: September 11, 2020
Phase:
Study type: Observational

A Respiratory infection with the SARS-CoV2 virus is associated with a major risk of viral pneumonia that can lead to respiratory distress requiring resuscitation. In the most severe forms, it may require mechanical ventilation or even lead to an acute respiratory distress syndrome with a particularly poor prognosis. The SARS-CoV2 is a single-stranded RNA virus of positive polarity and belongs to the beta genus of Coronaviruses. SARS-CoV2 is responsible for the third epidemic in less than twenty years secondary to a Coronavirus (SARS-CoV then MERS-CoV) and if the mortality associated with it is lower than that of previous strains, notably MERS-CoV, its spread is considerably big. As a result, the number of patients developing respiratory distress requiring invasive mechanical ventilation is high, with prolonged ventilation duration in these situations

NCT ID: NCT04484727 Recruiting - Clinical trials for Ventilator Associated Pneumonia

"Lung Barometric Measurements in Normal And in Respiratory Distressed Lungs"

LUNAR
Start date: May 1, 2022
Phase:
Study type: Observational

Little is known about how lung mechanics are affected during the very early phase after starting mechanical ventilation. Since the conventional method of measuring esophageal pressure is complicated, hard to interpret and expensive, there are no studies on lung mechanics on intensive care patients directly after intubation, during the first hours of ventilator treatment and forward until the ventilator treatment is withdrawn. Published studies have collected data using the standard methods from day 1 to 3 of ventilator treatment for respiratory system mechanics, i.e. the combined mechanics of lung and chest wall. Consequently, information on lung mechanical properties during the first critical hours of ventilator treatment is missing and individualization of ventilator care done on the basis of respiratory system mechanics, which are not representative of lung mechanics on an individual patient basis. We have developed a PEEP-step method based on a change of PEEP up and down in one or two steps, where the change in end-expiratory lung volume ΔEELV) is determined and lung compliance calculated as ΔEELV divided by ΔPEEP (CL = ΔEELV/ΔPEEP). This simple non-invasive method for separating lung and chest wall mechanics provides an opportunity to enhance the knowledge of lung compliance and the transpulmonary pressure. After the two-PEEP-step procedure, the PEEP level where transpulmonary driving pressure is lowest can be calculated for any chosen tidal volume. The aim of the present study in the ICU is to survey lung mechanics from start of mechanical ventilation until extubation and to determine PEEP level with lowest (least injurious) transpulmonary driving pressure during ventilator treatment. The aim of the study during anesthesia in the OR, is to survey lung mechanics in lung healthy and identify patients with lung conditions before anesthesia, which may have an increased risk of postoperative complications.

NCT ID: NCT04467892 Completed - Clinical trials for Ventilator Associated Pneumonia

Low Versus High Corticosteroid Use in Ventilator Associated Pneumonia

Start date: January 2, 2018
Phase: Phase 2
Study type: Interventional

patients who had >3 on Murray score and >6 on CPIS allocated randomly in two groups 120 patients in each. Group A received 30 mg/kg methyl-prednisolone slowly intravenous in 250 mL normal saline every 8 hours for only 48 hours while group B received 1 mg/kg/day methyl-prednisolone divided to three doses given every 8 hours for two weeks. Duration of the study last 16 days, Morbidity considered if no improvement in any or all clinical parameters of both Murray and CPIS scores and failure of weaning of patients from the ventilator at the studied period.

NCT ID: NCT04402359 Completed - Clinical trials for Ventilator Associated Pneumonia

Usage of Meropenem/Gentamicin Versus Ceftazidime/Avibactam in ARDS

Start date: July 5, 2018
Phase:
Study type: Observational [Patient Registry]

This was a prospective double blind study conducted on 200 polytrauma patients admitted to King Abdul-Aziz Specialized Hospital, Taif, KSA between July 2018 and December 2019 in surgical ICU. All patients were having severe chest trauma, contused lungs either with or without severe head trauma.

NCT ID: NCT04397952 Completed - Clinical trials for Ventilator Associated Pneumonia

Endotracheal Tube Cuff Pressure Measurement

Start date: November 1, 2017
Phase:
Study type: Observational [Patient Registry]

The effect of endotracheal cuff pressure measurement technique for preventing ventilatory associated pneumonia.

NCT ID: NCT04381247 Recruiting - Infectious Disease Clinical Trials

Comprehensive Molecular Diagnosis and Management of Hospital- and Ventilator-associated Pneumonia in Norway

HVAPNOR
Start date: June 15, 2021
Phase:
Study type: Observational [Patient Registry]

HVAPNOR consists of Three work packages: 1. Prospective observational study of Hospital (HAP) - and ventilator-Associated pneumonia (VAP) at 5 hospitals in Norway. Establish optimized routines for microbiological sampling, diagnostics and antibiotic stewardship.. 2. Biomarker studies in HAP and VAP. 3. Studies on capacity building in HAP and VAP diagnostics.

NCT ID: NCT04372576 Recruiting - Clinical trials for Corona Virus Infection

Epidemiology and Outcome of Ventilator-associated Pneumonia Among Critically Ill COVID-19 Patients

Start date: April 16, 2020
Phase:
Study type: Observational

The aim of this study is to determine the risk factors for development of ventilator-associated pneumonia (VAP) and to identify the prognostic factors of VAP among Coronavirus Disease 2019 (CoViD-19) patients. We hypothesized that CoViD-19 serves as a high risk factor for the development of VAP and it affects clinical outcome measures negatively.