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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT03530319
Other study ID # 201712140MIND
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date November 10, 2018
Est. completion date December 31, 2021

Study information

Verified date July 2021
Source National Taiwan University Hospital
Contact Chun-Yi Lu, MD, PhD
Phone 886-2-23123456
Email cylu@ntu.edu.tw
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

A randomized clinical trial comparing treatment effectiveness of azithromycin and doxycycline for pediatric Mycoplasma pneumonia.


Description:

Mycoplasma pneumoniae accounts for 10-30% of community-acquired pneumonia (CAP) in children. Proportionally, M. pneumoniae has become the most important pathogen for childhood pneumonia after the widespread use of Streptococcus pneumoniae vaccines. M. pneumoniae is routinely treated with antibiotics, and the macrolides antibiotics are the drug of choice for M. pneumonia infection. However, macrolide-resistance rates have increased to 20 and 100% in Asia. In previous studies, the most common mutation point, A2063G, was detected from 23% of local strains in Taiwan. The evolution and spreading of Mycoplasma in Taiwan and different countries are unknown. Genotyping based on multiple-locus variable-number tandem-repeat and resistance analysis (MLVA) will be used to study the classification and possibly the evolution of M. pneumoniae strains. While the macrolide-resistance is increasing, the optimal therapy remains unclear. Both tetracyclines and fluoroquinolones showed promises in treating macrolide-resistant M. pneumoniae in adults. However, their use in children is not recommended due to safety concerns. Recently, evidence are accumulating that doxycycline, unlike other tetracyclines, does not cause staining of teeth. In the current study, the investigators are going to carry out a randomized control trial to compare the efficacy and safety of doxycycline against macrolide-resistant M. pneumoniae. On the other hand, the investigators are going to update the macrolide-resistant rates in Taiwan and analyze M. pneumoniae strains in Taiwan by MLVA. By using this rapid and highly discriminatory tool, the investigators could provide more reliable information about the relationship between resistance strains


Recruitment information / eligibility

Status Recruiting
Enrollment 100
Est. completion date December 31, 2021
Est. primary completion date December 31, 2021
Accepts healthy volunteers No
Gender All
Age group 1 Year to 18 Years
Eligibility Inclusion Criteria: - Children aged 1-18 years, admitted due to lower respiratory tract infections. Mycoplamsa pneumonia is diagnosed. - The diagnosis is made within 72 hours after fever onset. - The patient and his/her guardians are willing to participate the study and able to follow the instruction. Exclusion Criteria: - Patients who have already taken macrolides, tetracyclines, or fluoroquinolones. - Patient's with congenital or acquired immunodeficiency. - Severe patients who needs ICU care. - Patients or their guardians who are not willing to participate in the study.

Study Design


Intervention

Drug:
Doxycycline
Oral doxycycline is given with a dosage of 2-4 mg/kg/day divided into twice a day for 5-10 days.
Azithromycin
Azithromycin is given with a dosage of 10 mg/kg/day once a day for 3 days.

Locations

Country Name City State
Taiwan National Taiwan University Hospital Taipei

Sponsors (1)

Lead Sponsor Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type Measure Description Time frame Safety issue
Primary Defervescence The timing (days) when fever subsides after treatment Up to 10 days
Secondary Hospital stay The length of hospitalization Up to 2 weeks