Pleural Effusion Clinical Trial
Official title:
Local Anesthetic Thoracoscopy Versus Ultrasound Guided Pleural Biopsies and Repeat Thoracocentesis in Pleural Effusion After Inconclusive Initial Thoracentesis: a Randomized Study
Pleural fluid can be caused by cancer. Patients with repeated presentation of pleural fluid
where initial diagnostic tests have been inconclusive are the focus of this trial. In this
clinical trial patients are randomized into two groups and the efficacy of local anesthetic
thoracoscopy (LAT) is compared to an ultrasound guided biopsy of the outer lining of the
lung. The aim is not only the diagnostic yield in diagnosing cancer, but also the procedures
ability to diagnose specific cancer mutations and immune system markings.
Methods and objectives:
Patients with reoccuring one-sided pleural fluid, with a marked clinical risk of cancer based
on findings in medical work-up, radiological scans, biochemistry and medical history and who
are undiagnosed upon initial pleural fluid analysis are the target patients of the trial.
Patients are randomized into two groups to have undertaken either pleural biopsy at the
optimal site for a repeat thoracentesis or LAT. Thus diagnostic yield for both fluid analysis
and biopsy analysis will be compared to tissue samples taken with LAT.
We hypothesize that LAT is superior both to pleural biopsy and repeat thoracentesis in
providing diagnostic clarification and providing sufficient basis for treatment without
further procedures resulting in less time consumption, cost and discomfort for the patient.
n/a
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