Clinical Trials Logo
  1. Home
  2. Pleural Effusion
  3. NCT02192138

Pathophysiological Effects of Intrapleural Pressure Changes During Therapeutic Thoracentesis

Pleural Effusion Clinical Trial

Official title:
Ventilation, Gas Exchange and Cardiac Function in Relation to Intrapleural Pressure Changes in Patients Undergoing Therapeutic Thoracentesis

Clinical Trial Summary

Research project objectives. The project includes eight research hypotheses and eight corresponding study objectives. The most relevant objectives are: - Analysis of lung function and gas exchange parameters in relation to the removed pleural fluid volume and intrapleural pressure changes. - Evaluation of changes in lung and chest wall compliance and related changes in work of breathing during therapeutic thoracentesis and pleural fluid withdrawal. - Study of the relationship between intrapleural pressure changes and cardiac function assessed by echocardiography and alterations in serum natriuretic peptide A and B concentration. - Comparative analysis of the reliability of the volume-pressure curve slope prediction based on different variables measured before thoracentesis and real measurements of ventilation and intrapleural pressure during thoracentesis. 2. Research methodology The study will be performed in 60 patients with pleural effusion planned for therapeutic thoracentesis. Studies before thoracentesis: body plethysmography, spirometry, lung diffusion capacity (DLCO), arterial blood gases, 6 minute walk test, echocardiography, serum natriuretic peptide concentration. Evaluation during thoracentesis: continuous measurement of tidal breathing and respiratory rate, measurement of removed pleural fluid volume and intrapleural pressure, transcutaneous measurement of PO2 and PCO2. Pleural catheter will be retained for the next 48hours to enable fluid drainage and intrapleural pressure measurement after completion of thoracentesis. Monitoring during 48-hrs after thoracentesis: pre-thoracentesis measurements will be repeated in specific time points and compared in two subgroups (active physiotherapy to improve lung re-expansion and passive lung re-expansion). Intrapleural pressure will be measured 24 and 48 hours after thoracentesis. Then, the catheter will be removed. Analysis.Signal analysis and visual multidimensional analysis performed with the use of own computer programs will be the first step of the analysis. The identified relationships between the analyzed parameters should allow to form physiological, medical, and statistical hypotheses, as well to verify the analysis of previously obtained data . Expected impact of the research project The study results will allow to define lung function, blood gases and cardiovascular function in relation to changes in intrapleural pressure. Some of these correlations had not been previously investigated. Our results may influence management standards in patients who require therapeutic thoracentesis.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02192138
Study type Interventional
Source Medical University of Warsaw
Contact
Status Completed
Phase N/A
Start date August 2014
Completion date January 2019
View Details
See also
  Status Clinical Trial Phase
Completed NCT04159831 - A Study to Evaluate LTI-01 in Patients With Infected, Non-draining Pleural Effusions Phase 2
Recruiting NCT02891642 - Liquid Biopsy With Immunomagnetic Beads Capture Technique for Malignant Cell Detection in Body Fluid
Completed NCT02232841 - Electrical Impedance Imaging of Patients on Mechanical Ventilation N/A
Completed NCT02045641 - Pleural and Pericardial Effusion Following Open Heart Surgery N/A
Completed NCT01948076 - Evaluation of a Pocket-Sized Ultrasound Device As an Aid to the Physical Examination N/A
Completed NCT01416519 - Physiotherapy Technique Decreases Respiratory Complications After Cardiac Operation N/A
Completed NCT01560078 - Efficacy Study of Thrice Weekly Directly Observed Treatment Short-Course Regimen in Tubercular Pleural Effusion N/A
Completed NCT04891705 - Point of Care Ultrasound Lung Artificial Intelligence (AI) Validation Data Collection Study
Recruiting NCT05759117 - Prospective Evaluation of Patients With Pleural Effusion
Recruiting NCT05910112 - Prospective Data Collection on Clinical, Radiological and Patient Reported Outcomes After Pleural Intervention
Completed NCT03896672 - Clinical Implementation of the Use of Positive Pressure in Chest Drainage N/A
Active, not recruiting NCT06075836 - AI Assisted Detection of Chest X-Rays
Recruiting NCT03728491 - Education and Training Competences in Thoracic Ultrasound N/A
Not yet recruiting NCT03260088 - Evaluation Of Pleural Effusion At Assiut University Hospital N/A
Completed NCT03535883 - The Safety of Thoracentesis, Tunneled Pleural Catheter, and Chest Tubes in Patients Taking Novel Oral Anti-Coagulants
Completed NCT03296280 - Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program
Completed NCT03661801 - Novel Pleural Fluid, Biopsy and Serum Biomarkers for the Investigation of Pleural Effusions
Completed NCT01778270 - Not Invasive Monitoring of Pleural Drainage N/A
Terminated NCT00402896 - Malignant Pleural Effusion With ZD6474 Phase 2
Recruiting NCT00103766 - Alteplase for Treatment of Empyema and Complicated Parapneumonic Effusion N/A