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Alteplase for Treatment of Empyema and Complicated Parapneumonic Effusion

Pleural Effusion Clinical Trial

Official title:
Randomized Comparison of Two Dose and Frequency Regimens of Alteplase for Treatment of Empyema and Complicated Parapneumonic Effusion

Clinical Trial Summary

The purpose of this study is to assess the benefit to patients with empyema or complicated parapneumonic effusion (CPE) using a daily versus twice daily Alteplase regimen of two different dose strategies compared with saline placebo.

Clinical Trial Description

This is a randomized, double-blind, placebo-controlled pilot study. Patients with empyema and complicated parapneumonic effusion who are felt to require fibrinolytic therapy will be considered for study enrollment. Enrolled patients will be randomized to one of five potential treatment arms (saline placebo, 4 mg once daily, 4 mg twice daily, 10 mg once daily, or 10 mg twice daily) in a double-blinded manner. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00103766
Study type Interventional
Source O'Brien, Jeana D., MD, FACP, FCCP
Contact Delores Gautier, RN, MSN
Phone 254-724-1769
Email lgautier@swmail.sw.org
Status Recruiting
Phase N/A
Start date October 2004
View Details
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