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Platinum Resistance clinical trials

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NCT ID: NCT04651933 Recruiting - Clinical trials for Epithelial Ovarian Cancer

A Training Set for the HRD Model in EOC

Start date: November 26, 2020
Phase:
Study type: Observational

A homologous recombination deficiency (HRD) scoring model based on loss of heterozygosity (LOH) is little explored in epithelial ovarian cancer (EOC) patients. This study would recruit 200 Chinese EOC patients with known BRCA1/2 mutation status and resistance to platinum-based chemotherapy. A LOH-HRD model is to be constructed based on the genetic testing in these patients. The mutated genes, HRD score model and their relationship with the prognosis, would provide a full description of for the Chinese EOC patients, and a potential explanation of platinum-resistance in such population.