Clinical Trials Logo

Clinical Trial Summary

this clinical trial aims to prove that multiple injections will produce a steady rate of acceleration of orthodontic tooth movement.


Clinical Trial Description

Platelet-rich fibrin injection is a second-generation platelet concentrate, prepared from centrifuged blood which is a rich source of platelets, stem cells, and growth factors seven times greater than that released by platelet-rich plasma. It is a simplified procedure with no biochemical manipulation of blood, free from anticoagulants which are known to inhibit wound healing or any gelling agent, and easily usable with a low rate of mistakes during the preparation procedure. A variety of growth factors are released by PRF such as platelet-derived growth factor (PDGF), transforming growth factor β (TGF-β), and vascular endothelial growth factor (VEGF), which play a crucial role in angiogenesis, collagen synthesis, and bone regeneration. Treatment with extraction especially in adult patients may take a longer time due to reported increase in bone density and lower bone regenerative rate. Also, the retraction process to close extraction spaces most of the time is accompanied by bone loss and root resorption as reported in the previous studies. i-PRF can accelerate tooth movement, in addition, prevent tooth retraction undesirable side effects. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05766618
Study type Interventional
Source Cairo University
Contact Mohamed M Alkhawaga, BDS
Phone +201099345694
Email mohamed.mamdouh@dentistry.cu.edu.eg
Status Recruiting
Phase Phase 3
Start date April 1, 2023
Completion date October 1, 2024

See also
  Status Clinical Trial Phase
Active, not recruiting NCT02918240 - How Often Should We See Our Orthodontic Patients N/A
Recruiting NCT04105491 - Patient's Expectations, Preferences, Experiences Before, During and After the Treatment With Invisalign® Aligners
Active, not recruiting NCT03967002 - Treatment of the Mandibular Dental Crowding With and Without Corticotomy Surgery N/A
Completed NCT02796911 - Comparative Study of Different Bone Grafts in Accelerating Tooth Movement N/A
Recruiting NCT05650359 - Study of the Use of Orthopulse Photobiomodulation N/A
Completed NCT03765151 - The Effectiveness of Low-level Laser Therapy in Orthodontic Retention for Periodontal-compromised Patients N/A
Completed NCT02901678 - The Effect of Different Force Magnitudes on Maxillary Posterior Segment Intrusion N/A
Not yet recruiting NCT01475773 - Psychological Assessment of Adults Seeking Orthodontic Treatment N/A
Completed NCT03070444 - Vacuum-formed Retainer Versus Bonded Retainer to Prevent Relapse After Orthodontic Treatment N/A
Enrolling by invitation NCT05814991 - A Cohort Prospective Study of Predictors Influencing the Quality of Visualization of the Operating Field During Orthognathic Surgery
Completed NCT03924726 - Osseous Evidence Behind Micro-osteoperforation in Accelerating Tooth Movement. N/A
Recruiting NCT06380790 - Effect of Laser-aided Csf on the Rate of Leveling and Alignment of Mandibular Anterior Crowding N/A
Active, not recruiting NCT00871026 - Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) - Based Planning and Creation of Orthodontic Appliances N/A
Completed NCT05562986 - Impacts of Oral Irrigation in Orthodontic Patients N/A
Recruiting NCT06167278 - Indirect Bonding Accuracy of 3D Printed Digital Transfer Trays N/A
Completed NCT03421886 - Assessment of the Efficacy of the Aerodentis System N/A
Completed NCT03714087 - Occlusal Outcomes by OGS After a Finishing Protocol N/A
Withdrawn NCT03332082 - A Commercial Available Tooth Positioner for the Treatment of Simple Orthodontic Relapse N/A
Completed NCT01246830 - The Use of 2D and 3D Imaging Modalities and Its Influence on Diagnosis and Treatment Planning in Orthodontics N/A
Active, not recruiting NCT00871091 - Study Investigating Tooth Movements With Conventional and Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) Supported Fixed Appliances N/A