Platelet Reactivity With Fentanyl, Morphine, or no Narcotic

Status Recruiting

Clinical Trial Summary

The goal is to determine whether fentanyl and morphine have similar effects in reducing aspirin's effect upon platelets in emergency department patients with chest discomfort. Morphine has been shown to worsen outcomes in heart attack patients due to reduction of oral anti-platelet agent effectiveness and so many providers have switches to using fentanyl. However, it is largely unknown whether fentanyl has similar effects.

Clinical Trial Description

Patients presenting to the emergency department with chest discomfort who are being administered aspirin will be offered enrollment in this study. At the time of their zero and two hour troponin we will also draw platelet aggregration studies to determine the effects of aspirin upon platelets. Narcotic medicines slow the absorption of aspirin. Morphine has therefore been shown to decrease the effectiveness of aspirin. Many providers therefore use fentanyl instead, however little is known about the effects of fentanyl upon aspirin. We will therefore compare the platelet reactivity of patients receiving morphine, fentanyl, or no narcotics ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05367336
Study type	Interventional
Source	Spectrum Health - Lakeland
Contact	Monique Luna
Phone	2699858679
Email	monique.allen@spectrumhealth.org
Status	Recruiting
Phase	Early Phase 1
Start date	August 31, 2022
Completion date	May 2024

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