Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations

Platelet Function Clinical Trial

Official title:

Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01352923
• Other study ID #: B322201111373
• Status: Recruiting
• Phase: N/A
• First received: May 11, 2011
• Last updated: May 11, 2011
• Start date: May 2011

Study information

• Verified date: May 2011
• Source: Universitaire Ziekenhuizen Leuven
• Contact: Alexandre Kauskot
• Email: alexandre.kauskot[@]med.kuleuven.be
• Is FDA regulated: No
• Health authority: Belgium: Federal Agency for Medicinal Products and Health Products
• Study type: Interventional

Clinical Trial Summary

In this study PEAR1 polymorphisms effects will be analyze in blood platelets to determine how PEAR1 regulates platelet activation.

Description:

Several large-scale studies have confirmed the long held notion that platelet responses to different agonists are highly variable, within well defined populations of healthy donors. Single nucleotide polymorphisms in genes encoding platelet proteins can explain the wide range of responses to standard platelet agonists. Yet, numerous SNPs point towards proteins with previously unknown function in platelets, wich modulate the complex network of signaling events that regulate platelet function and further augment variability. PEAR1 is mainly expressed in platelets and endothelial cells. A few studies have linked SNPs in PEAR1 with decreased or increased platelet responses to various agonists. However, hitherto, no direct functional studies have been carried out to determine whether and how PEAR1 modulate intracellular signaling pathways relevant for platelet function.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. primary completion date: May 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• healthy voluntary donors

Exclusion Criteria:

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Platelet Function

Intervention

Other:
• blood test
preparation of blood platelets

Locations

Country	Name	City	State
Belgium	KUleuven/UZ Gasthuisberg	Leuven	Vlaams Brabant

Sponsors (1)

Lead Sponsor	Collaborator
Universitaire Ziekenhuizen Leuven

Country where clinical trial is conducted

Belgium,