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Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine — EFFORT  

Malaria, Vivax Clinical Trial

Official title:
Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine - a Randomized Controlled Trial in P. Vivax Patients

Clinical Trial Summary

Health care facility based, randomized, controlled, open label, superiority trial with 3 arms

Clinical Trial Description

- To assess the effectiveness of a short-course of high dose primaquine (total dose 7mg/kg given unsupervised over 7 days) compared to the current standard low dose primaquine regimen (total dose 3.5mg/kg given unsupervised over 14 days). - To assess the effectiveness of tafenoquine (single dose of 300mg) compared to the short-course high dose primaquine regimen. - To assess the safety of tafenoquine compared to the high and low dose primaquine regimens. - To assess the cost-effectiveness and feasibility of high dose primaquine and tafenoquine compared to the current low dose primaquine regimen ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04411836
Study type Interventional
Source Menzies School of Health Research
Contact Kamala Thriemer, MD, MPH, PhD
Phone 0889468644
Email kamala.ley-thriemer@menzies.edu.au
Status Recruiting
Phase Phase 3
Start date April 25, 2021
Completion date September 30, 2024
View Details
See also
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