Multiple Myeloma Clinical Trial
Official title:
Chemotherapy and Anti-angiogenic Agents- Induced Thrombosis in Cancer.
RATIONALE: Studying samples of blood in the laboratory from patients receiving chemotherapy
may help doctors learn more about the effects of chemotherapy on cells. It may also help
doctors understand how patients respond to treatment.
PURPOSE: This research study is studying biomarkers related to thrombosis in patients with
newly diagnosed multiple myeloma receiving chemotherapy.
OBJECTIVES:
Primary
- To measure levels of circulating tissue factor (TF) in patients with newly diagnosed
multiple myeloma at several time points before, during, and after the administration of
chemotherapy and/or antiangiogenic agents.
Secondary
- To measure the correlation of TF with two markers of coagulation activation (i.e.,
D-dimer, thrombin-antithrombin [TAT] complexes) and two markers of endothelial
activation (i.e., soluble E-selectin, soluble thrombomodulin) in these patients.
- To measure and compare (descriptively) our microparticle-associated TF procoagulant
activity assay with two other assays using samples from these patients.
OUTLINE: Patients undergo blood sample collection at baseline and then periodically during
treatment. Circulating tissue factor (TF) activity levels and coagulation and endothelial
activation (by ELISA) are measured. Medical charts are reviewed for sociodemographic and
medical information.
After completion of study, patients are followed up for 3 months.
;
Time Perspective: Prospective
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