Plantar Wart Clinical Trial
Official title:
The Efficacy of Intralesional Injection of Combined Digoxin and Furosemide Versus 5-Flurouracil in the Treatment of Plantar Warts
The aim of the current work is to evaluate the efficacy and safety of intralesional combined Digoxin and furosemide versus intralesional 5-flurouracil in the treatment of plantar warts.
Warts are benign proliferations of skin and mucosa caused by the human papilloma virus (HPV). Currently, over 170 HPV types have been identified. Certain HPV types tend to infect skin at specific anatomical sites, such as palmoplantar warts, which are typically caused by serotypes 1, 2, and 4, however warts caused by any HPV type can occur at any site (Tulay & Serakinci, 2016). Plantar warts most commonly present with pain that occur with activities that put pressure on the soles of the feet. They commonly affect plantar areas of increased pressure, such as the heels or metatarsal heads. On gross inspection, plantar warts may appear as a singular rough, flesh-colored to yellow or grey-brown, hyperkeratotic papule, or a thickened "cobblestoned" plaque, termed a mosaic wart, which consists of multiple plantar warts that have coalesced (Witchey et al., 2018). There are several modalities for the treatment of warts including, cryotherapy, electrocoagulation, topical salicylic acid, topical 5-fluorouracil, intralesional immunotherapy, and laser surgery. All these treatment options can be painful, time-consuming, and/or expensive, and none is considered the gold standard (Latif et al., 2021). K+ influx is essential for the replication of DNA viruses, such as HPV. Both digoxin, which is a cardiac glycoside, and furosemide, which is a loop diuretic, inhibit the K+ influx by interacting with cell membrane ion co-transporters (Na+/K+-ATPase and Na+-K+-2Cl-co-transporter-1). Therefore, it is hypothesized that these two compounds may be valuable in the treatment of HPV-induced warts. This new approach is called ionic contra-viral therapy (Rijsbergen et al., 2019). Intralesional injection of combined digoxin and furosemide was found to be safe and effective as a treatment option for multiple plantar warts (Fathy et al., 2021). 5-Fluorouracil (5-FU) is an antimetabolite that can be used alone or with other chemotherapeutic agents to treat solid tumors. It is one of the pyrimidine analogues. Due to its structure, 5-FU disrupts nucleoside metabolism and can be integrated into the single and double helix of RNA and DNA, respectively, causing cell cytotoxicity and death (Zoheir et al., 2022). Intralesional 5-fluorouarcil has been found to be a highly effective, safe and cheap alternative in the treatment of warts, with a significantly good response in genital warts also (Kamal et al., 2108). ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT05324904 -
Intralesional Vitamin D3 Versus Intralesional Acyclovir in Treatment of Plantar Warts
|
N/A | |
Completed |
NCT00328991 -
Clinical Trial Evaluating Efficacy of Duct Tape for Treatment of Warts
|
N/A | |
Completed |
NCT05592041 -
Studying of Natural Constituents' Treatment of Plantar Warts
|
Early Phase 1 | |
Completed |
NCT05115669 -
Safety & Effectiveness of Wortie Freeze Plus in Common and Plantar Warts
|
N/A | |
Recruiting |
NCT06261684 -
Intralesional Acyclovir Versus Cryotherapy in the Treatment of Plantar Warts. A Randomized Controlled Trial.
|
Phase 2/Phase 3 | |
Not yet recruiting |
NCT05057663 -
Intralesional Treatment of Plantar Wart
|
N/A | |
Recruiting |
NCT02151630 -
Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts
|
Phase 2/Phase 3 | |
Withdrawn |
NCT04823845 -
Plantar Wart Treatment Using Adapalene Gel
|
Early Phase 1 | |
Completed |
NCT05588999 -
Comparative Study Between Treatment With Cryotherapy Alone Versus Cryotherapy Plus Salicylic Acid Dressing for Planter Warts
|
Phase 1 | |
Completed |
NCT01536834 -
Safety & Performance Study of Verruca Treatment Device
|
N/A | |
Recruiting |
NCT05488860 -
Piezoelectric Drived Microneedling in Treating Refractory Skin Diseases
|
N/A | |
Recruiting |
NCT05520658 -
Evaluation of the Efficacy of Intralesional Injection of Combined Digoxin and Furosemide Versus 5 - Fluorouracil in Treatment of Plantar Warts
|
N/A | |
Not yet recruiting |
NCT04654091 -
Cryotherapy VS. Nitric-zinc Complex in the Treatment of Plantar Warts.
|
N/A | |
Not yet recruiting |
NCT05198180 -
Treatment of Plantar Warts
|
Phase 3 | |
Recruiting |
NCT06214559 -
Evaluate the Effectiveness and the Safety of a Medical Device in the Treatment of Common Warts and Plantar Warts.
|
N/A | |
Recruiting |
NCT03977753 -
Randomized, Placebo-controlled, Double Blind Study to Evaluate the Efficacy of 2LVERU®JUNIOR and 2LVERU® on the Treatment of Warts
|
Phase 4 | |
Completed |
NCT03183765 -
Intralesional Measles, Mumps, Rubella (MMR) Vaccine Versus Cryotherapy in Treatment of Multiple Common and Planter Warts
|
Phase 4 |