Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts

Plantar Wart Clinical Trial

Official title:

Comparison of 70% Pyruvic Acid Solution and Duofilm Solution in Treatment of Plantar Wart

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02151630
• Other study ID #: 393219
• Status: Recruiting
• Phase: Phase 2/Phase 3
• First received: May 28, 2014
• Last updated: May 29, 2014
• Start date: May 2014
• Est. completion date: September 2014

Study information

• Verified date: May 2014
• Source: Isfahan University of Medical Sciences
• Contact: Fatima Assaf, M.D.
• Phone: 0098 913 0965384
• Email: dr.assafsaid[@]gmail.com
• Is FDA regulated: No
• Health authority: Iran: Ministry of Health
• Study type: Interventional

Clinical Trial Summary

Plantar warts can be bothersome and painful requiring treatment. The investigators will compare the efficacy of pyruvic acid and salicylic acid in treating multiple plantar warts. Patients with multiple plantar warts will be randomized to receive either pyruvic acid 70% or compound salicylic acid solution (salicylic acid 16.7%, lactic acid 16.7%, and collodion 100%) applying topically twice a day for 4 weeks. Patients will be visited every 2 weeks for one month after starting treatment and then every one month for up to 3 months. The number and size of warts will be evaluated.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 60
• Est. completion date: September 2014
• Est. primary completion date: September 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 12 Years and older

Eligibility

Inclusion Criteria:

• aged 12 years and above

• multiple warts (at least 2)

Exclusion Criteria:

• mosaic warts

• already under any treatment for warts

• pregnant or lactating women

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Foot Diseases
• Plantar Wart
• Warts

Intervention

Drug:
• Pyruvic acid

• Salicylic Acid

Locations

Country	Name	City	State
Iran, Islamic Republic of	Skin Diseases and Leishmaniasis Research Center	Isfahan

Sponsors (1)

Lead Sponsor	Collaborator
Isfahan University of Medical Sciences

Country where clinical trial is conducted

Iran, Islamic Republic of, 

References & Publications (1)

Kwok CS, Holland R, Gibbs S. Efficacy of topical treatments for cutaneous warts: a meta-analysis and pooled analysis of randomized controlled trials. Br J Dermatol. 2011 Aug;165(2):233-46. doi: 10.1111/j.1365-2133.2011.10218.x. Epub 2011 May 26. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Wart number	Patients will be visited every two weeks for one month and then every month for up to 3 months by a dermatologist. On each visit, warts will be inspected to determine the number of warts. Any wart totally non-detectable by inspection and touch will be considered as healed.	From before to 3 months after	No
Primary	Wart size	Patients will be visited every two weeks for one month and then every month for up to 3 months by a dermatologist. On each visit, warts will be inspected to determine the size of warts. The size of the warts will be calculated as the mean size of all the warts.	From before to 3 months after	No