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Management of Early-onset Fetal Growth Restriction: Angiogenic Factors Versus Feto-placental Doppler — earlyGRAFD  

Preeclampsia Clinical Trial

Official title:
Management of Early-onset Fetal Growth Restriction: Angiogenic Factors Versus Feto-placental Doppler (Early GRAFD)

Clinical Trial Summary

This is a multicentre, open-label, randomized controlled trial. A total of 340 singleton pregnancies with an EFW ≤10th percentile between 26+0 and 31+6 weeks will be recruited and randomly allocated to either the control or the intervention group. In the control group, standard Doppler-based management will be used. In the intervention group, different soluble fms-like tyrosine kinase to placental growth factor ratio (sFlt-1/PlGF) cutoffs will be incorporated to the current protocol to adjust the frequency of ultrasounds and to plan elective delivery.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05284474
Study type Interventional
Source Hospital Universitari Vall d'Hebron Research Institute
Contact Manel Mendoza, MD, PhD
Phone +34934893000
Email manel.mendoza@vallhebron.cat
Status Not yet recruiting
Phase N/A
Start date June 3, 2024
Completion date December 30, 2026
View Details
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