Neuromuscular Responses to Acute Beetroot Ingestion in Women Older Adults

Placebo Clinical Trial

— BEET_ELDERLY  

Official title:

Neuromuscular Responses to Acute Beetroot Ingestion in Women Older Adults. Performance and Side Effects

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05337527
• Other study ID #: uFrancisco_Vitoria_
• Status: Completed
• Phase: N/A
• Start date: March 1, 2022
• Est. completion date: April 10, 2022

Study information

• Verified date: May 2022
• Source: Universidad Francisco de Vitoria
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Beetroot juice supplementation has shown the capacity for provoking different physiological effects (e.g. vasodilation and muscle contraction increments). However, the effects of beetroot juice ingestion on neuromuscular performance in women older adults are barely studied. In this randomized placebo-controlled study, we investigated the effects of beetroot acute supplementation in improving neuromuscular performance in women older adults

Description:

Beetroot juice supplementation has shown the capacity for provoking different physiological effects that could affect human performance (e.g. vasodilation and muscle contraction increments). Although this dietary supplement has been commonly used for improving sports performance in recreational or professional athletes, the scientific literature in older adults is scarce. Thus, in our knowledge, no previous studies have analyzed the side effects associated to ingestion in this population group. In this randomized placebo-controlled study, we investigated the effects of beetroot acute supplementation in improving neuromuscular performance and side effects associated with ingestion in women older adults.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 9
• Est. completion date: April 10, 2022
• Est. primary completion date: March 18, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 65 Years to 80 Years

Eligibility

Inclusion Criteria:

• Women >65 or <85 years of age.
• In good health, as determined by the investigator's review of history. Exclusion Criteria: (based in previous studies on this topic (doi: 10.1093/gerona/glaa311). Men and women <65 or >85 years of age Unable to provide informed consent Current smokers Significant orthopedic limitations or other contraindications to strenuous exercise Those taking proton pump inhibitors, antacids, xanthine oxidase inhibitors, or on hormone replacement therapy Those taking anti-coagulants or on anti-platelet therapy History of neuromuscular disease (e.g., cervical spondylotic radiculomyelpathy, lumbar spondylosis, amyotrophic lateral sclerosis, Guillain-Barré syndrome, and acquired demyelinating polyneuropathies) Cardiovascular disease (e.g., > stage I hypertension, heart failure, myocardial infarction/ischemia significant myocardial or pericardial diseases (e.g. amyloidosis, constriction), Moderate or severe valvular disease, renal disease, liver disease, or anemia

Related Conditions & MeSH terms

• Dietary Supplement
• Placebo

Intervention

Dietary Supplement:
• beetroot juice
Acute effects of beetroot juice or placebo juice ingestion

Locations

Country	Name	City	State
Spain	Universidad Francisco de Vitoria	Pozuelo de Alarcón	Madrid

Sponsors (1)

Lead Sponsor	Collaborator
Universidad Francisco de Vitoria

Country where clinical trial is conducted

Spain, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in maximal isometric handgrip strength (N)	Using a dynamometer and measuring dominant/ non-dominant side	1-week
Primary	Changes in 6-m gait speed test	Using a photocell timing gates (seconds)	1-week
Primary	Changes in Time Up and Go test	Using a photocell timing gates (seconds)	1-week
Primary	Changes in Sit and Stand Test	Using Power Frail APP	1-week
Primary	6-Minute Walk Test		1-week
Secondary	Rate of perception effort (RPE)	Using a validated scale (1-10 points)	1-week
Secondary	Side effects questionnarie	Using a side-effects questionnarie (YES/NO scale)	1-week