View clinical trials related to Placebo.
Filter by:Background: - Stress can cause people to give in to temptations to eat less healthily. People who are on weight loss diets often have problems sticking to their diets when they are stressed. Some tests have shown that the drug pexacerfont can help reduce stress-related seeking of high-calorie foods. However, it has not been tested on reducing food craving. Researchers want to test pexacerfont on people who are on diets to see if it can reduce stress-related food cravings. Objectives: - To see if pexacerfont can help reduce stress-induced food cravings. Eligibility: - Individuals between 21 and 65 years of age who are on a diet to control their weight. Design: - Participants will be screened with a physical exam and medical history. This study requires seven visits over about 35 days. - Participants will take either pexacerfont or placebo pills during the study. They will have three pills every morning. They will record video of themselves taking the pills every day. - Every evening, participants will fill out a questionnaire. It will ask questions about feelings and behaviors related to eating and food craving. - Participants will have regular study visits while taking the pills. The visits will involve questions about stressful situations and food cravings. One visit will involve a mildly stressful math test, followed by tasting of different foods. This test will look at whether pexacerfont can affect food preferences. Participants will provide blood and saliva samples as directed at these study visits. - Participants will have follow-up phone calls 1, 3, and 6 months after the end of the study.