Clinical Trials Logo

Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT04938401
Other study ID # Neurosurgery 5 Ward
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date July 2, 2021
Est. completion date December 31, 2023

Study information

Verified date June 2021
Source Second Affiliated Hospital, School of Medicine, Zhejiang University
Contact YIing Wang
Phone 13588837622
Email Ukuk007@126.com
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

(1) Objective to establish an evaluation system for predicting the risk of epistaxis after endoscopic transsphenoidal pituitary surgery( 2) Objective to determine the risk factors of epistaxis after endoscopic transsphenoidal pituitary adenoma surgery. Referring to domestic and foreign literature, combined with experts' opinions, the related risk factors that may cause postoperative nosebleed of pituitary adenoma are: 22 patients and surgical factors. 3) Objective to establish a risk prediction model of epistaxis after endoscopic transsphenoidal pituitary tumor resection. According to the occurrence of epistaxis, the patients in the modeling group were divided into epistaxis group and non epistaxis group. The risk factors of epistaxis were taken as the independent variable, and the occurrence of epistaxis was taken as the dependent variable. The variables with statistical significance in univariate analysis were included in the multivariate logistic regression model, and the risk prediction model of epistaxis after pituitary tumor resection was established by back LR method.(4) Objective to verify the risk prediction model of endoscopic transsphenoidal pituitary adenoma epistaxis. The validation model is used to validate the prediction model, and the Hosmer-Lemeshow degree is used to match the model. The area under the receiver operating characteristic curve (ROC) was used to evaluate the validity of the model.(5) Application of risk prediction model.


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 1
Est. completion date December 31, 2023
Est. primary completion date October 31, 2021
Accepts healthy volunteers
Gender All
Age group 14 Years to 90 Years
Eligibility Inclusion Criteria: Those who met the diagnostic criteria of pituitary tumor and received transsphenoidal endoscopic surgery during hospitalization; Patients with informed consent; Age = 14 years old. Exclusion Criteria: quitters; patients with incomplete clinical data;

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
n/a

Sponsors (4)

Lead Sponsor Collaborator
Wang Ying supervisor nurse Sir Run Run Shaw Hospital, Zhejiang Provincial People's Hospital, Zhejiang University

Outcome

Type Measure Description Time frame Safety issue
Primary Incidence of epistaxis Overall incidence of epistaxis up to 24 weeks
See also
  Status Clinical Trial Phase
Not yet recruiting NCT04529356 - The TMS Treatment for Postoperative Headache in GH Tumor N/A
Completed NCT03363126 - Visual Outcome After Transsphenoidal Surgery for Pituitary Macroadenoma N/A
Completed NCT04212793 - Detection of PitNET Tissue During TSS Using Bevacizumab-800CW Phase 1
Recruiting NCT03309319 - A Pilot Study of Rosiglitazone in the Treatment of GH Secreting Pituitary Adenomas N/A
Terminated NCT04106531 - Validation of a Quality of Life Metric "Prolac-10"
Recruiting NCT03719781 - Postoperative Cognitive Dysfunction in Patients Undergoing Pituitary Removal Surgery
Recruiting NCT01556230 - Prospective Study of Clinically Nonfunctioning Pituitary Adenomas
Recruiting NCT03132259 - Comparative Low and High Dose of Dexmedethomidine in Pituitary Tumor Removal by Transphenoid Approach Phase 4
Recruiting NCT01368133 - The Observational Study of Growth Hormone-secreting Pituitary Tumors N/A
Withdrawn NCT04863339 - Tranexamic Acid for Blood Loss Minimization in Endoscopic Pituitary Surgery Phase 2
Terminated NCT00646308 - Assessment of Cardiovascular Risk Markers in Growth Hormone Deficient Patients With Nonsecreting Pituitary Adenomas N/A
Recruiting NCT00852501 - Characterization of Receptors in Non-functioning Pituitary Macroadenomas Phase 4
Completed NCT03465423 - Comparison of Propofol Requirement Between Patients With Pituitary Somatotroph Tumor and With Nonfunctioning Pituitary Tumor in Transsphenoidal Pituitary Surgery Under Total Intravenous Anesthesia
Recruiting NCT03474601 - Seoul National University Pituitary Disease Cohort Study
Recruiting NCT05139277 - Evaluation of the CONVIVO System N/A
Active, not recruiting NCT03636568 - Hyponatremia Study (Delayed Hyponatremia After Pituitary Surgery) N/A
Completed NCT02813044 - Effects of Total Intravenous Anesthesia With Propofol-remifentanil Versus Inhalational Anesthesia With Sevoflurane on Quality of Recovery in Patients Undergoing Transsphenoidal Surgery for Pituitary Tumor N/A
Recruiting NCT03973450 - Epidemiology of Pituitary Tumours: Prevalence of Associated Neoplasia
Active, not recruiting NCT04042753 - Nivolumab and Ipilimumab in People With Aggressive Pituitary Tumors Phase 2
Recruiting NCT04018963 - The Impact of Endoscopic Pituitary Surgery on Nasal Function