Insulin Resistance Clinical Trial
Official title:
Lipolytic Effects of GH in Hypopituitary Patients in Vivo: Molecular Mechanisms and Temporal Patterns.
Growth hormone (GH) is essential for longitudinal bone growth and somatic development. These
protein anabolic effects require sufficient nutritional supply. During fasting and caloric
restriction GH predominantly promotes fat metabolism.
GH counteracts the effect of insulin in many tissues, of which insulin-stimulated glucose
uptake in skeletal muscle has been most extensively studied. Substrate competition between
elevated free fatty acids and glucose is suggested as a mechanism, and this hypothesis can be
tested mechanistically by means of acipimox, which is a nicotinic acid that suppresses the
fat metabolizing effects of GH.
The hypothesis is, that the suppressive effect of GH on insulin-stimulated glucose uptake in
skeletal muscle is obviated by acipimox-induced inhibition of fat metabolism.
In order to investigate this, eight adult hypopituitary patients with documented
GH-deficiency will be studied in the presence and absence of GH and acipimox, respectively,
and biopsies from skeletal muscle and subcutaneous adipose tissue will be analyzed.
Knowledge of the effects of growth hormone and fat metabolism can in shot-sight as well as in
long-sight have great importance for the understanding of growth disorders from overweight
and type 2 diabetes to malnutrition and eating disorders.
n/a
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