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Dopamine D2 Receptors(D2R) Imaging in Nonfunctioning Pituitary Adenoma(NFPA)

Pituitary Adenoma Clinical Trial

Official title:
The Predictive Value of Positron Emission Tomography-Magnetic Resonance (PET-MR) Mediated Dopamine D2 Receptors Imaging in the Drug Therapy of Nonfunctioning Pituitary Adenoma

Clinical Trial Summary

To study the in vivo expression of dopamine D2 receptors in nonfunctioning pituitary adenoma and the predictive role of dopamine dopamine D2 receptors PET-MR imaging in the therapeutic effect of dopamine agonists（DA）.

Clinical Trial Description

Dopamine agonists are the first line therapy for prolactinoma,which are also effective in some cases of other subtypes of pituitary tumors. It had been showed that dopamine agonists inhibit prolactin secretion by binding to and activating dopamine D2 receptors. PET-MR combined MR images with PET function images is substantial to evaluate the expression of dopamine D2 receptors.The aim is to study the in vivo expression of dopamine D2 receptors in prolactinoma and the predictive role of dopamine D2 receptors PET-MR imaging in the therapeutic effect of dopamine agonists. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03714763
Study type Interventional
Source Ruijin Hospital
Contact Weiting Gu, MD
Phone 0086-13917778956
Email nowaiting1221@hotmail.com
Status Not yet recruiting
Phase N/A
Start date November 1, 2018
Completion date January 31, 2022
View Details
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