Pilot Study of Imaging Human Skin With High-Speed Spectrally Encoded Confocal Microscopy

Skin Lesion Clinical Trial

Official title: Pilot Study of Imaging Human Skin With High-Speed Spectrally Encoded Confocal Microscopy

Status Enrolling by invitation

Clinical Trial Summary

The aim of this study is to evaluate the imaging performance of Spectrally Encoded Confocal Microscopy (SECM) for imaging human skin and skin diseases.

Clinical Trial Description

SECM provides an order of magnitude faster imaging speed than conventional confocal microscopy devices. The investigators have previously utilized the SECM technology for imaging large area of human esophagus in vivo. They have also developed endoscopic capsule devices which have been used to safely image over 60 human subjects, healthy volunteers and subjects with eosinophilic esophagitis, using SECM technology, rapidly.

When used for skin imaging, SECM can provide real-time three-dimensional confocal imaging and significantly reduce the imaging time. While SECM has been successfully used for imaging human esophagus in vivo, its utility in skin imaging needs to be tested in a new pilot study. The investigators will be taking images with a dermatoscope as well. This will the control to compare the experimental images to, as the dermatoscope is the standard of care diagnostic tool for dermatologists. ;

Related Conditions & MeSH terms

• Nevus, Pigmented
• Pigmentation Disorders
• Pigmented Lesions
• Pigmented Moles
• Pigmented Skin Lesion
• Skin Lesion

• NCT number: NCT04566302
• Study type: Interventional
• Source: Massachusetts General Hospital
• Status: Enrolling by invitation
• Phase: N/A
• Start date: July 19, 2021
• Completion date: April 2025