PICS Clinical Trial
Official title:
The Impact of a Bundle of Preventive Measures for Post-intensive Care Syndrome on the Outcome of Critically Ill Patients
NCT number | NCT03398707 |
Other study ID # | PICS study |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | January 25, 2018 |
Est. completion date | June 30, 2019 |
Verified date | December 2018 |
Source | Hospital Sao Domingos |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational [Patient Registry] |
This prospective observational cohort study will investigate the impact of a bundle of nine preventive measures (Assessment, prevention and management of pain; spontaneous awaking trial; spontaneous breathing trial; choice of sedation and analgesia; delirium assessment, prevention and management; early mobility; family communication and ICU Diary) on the incidence and severity of Post-Intensive Care Syndrome (PICS) and clinical outcomes in critically ill patients
Status | Completed |
Enrollment | 300 |
Est. completion date | June 30, 2019 |
Est. primary completion date | December 31, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: . - Adult non pregnant patients - Length of ICU stay of at least 2 days. Exclusion Criteria: - Severe cognitive deficits prior to admission. - Traumatic brain injury with Glasgow coma scale < 14 - Stroke with Glasgow coma scale < 14 |
Country | Name | City | State |
---|---|---|---|
Brazil | Hospital Sao Domingos | Sao Luis | MA |
Lead Sponsor | Collaborator |
---|---|
Hospital Sao Domingos |
Brazil,
4. Torres J, Veiga C, Pinto F, et al. Post intensive care syndrome- from risk at ICU admission to 3 months follow-up clinic. Intensive Care Med Experimental 2015, 3 (Suppl 1): A448.
5. Ramnarain D, Rutten A, Van der Nat G, et al. The impact of post intensive care syndrome in patients surviving the ICU: the downside of ICU treatment. Intensive Care Med Experimental 2015, 3 (Suppl 1): A530.
de Azevedo JR, Montenegro WS, Rodrigues DP, de C Souza SC, Araujo VF, de Paula MP, Prazeres PH, da Luz Leitão A, Mendonça AV. Long-term cognitive outcomes among unselected ventilated and non-ventilated ICU patients. J Intensive Care. 2017 Feb 17;5:18. doi: 10.1186/s40560-017-0213-4. eCollection 2017. — View Citation
Iwashyna TJ, Ely EW, Smith DM, Langa KM. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA. 2010 Oct 27;304(16):1787-94. doi: 10.1001/jama.2010.1553. — View Citation
Needham DM, Davidson J, Cohen H, Hopkins RO, Weinert C, Wunsch H, Zawistowski C, Bemis-Dougherty A, Berney SC, Bienvenu OJ, Brady SL, Brodsky MB, Denehy L, Elliott D, Flatley C, Harabin AL, Jones C, Louis D, Meltzer W, Muldoon SR, Palmer JB, Perme C, Robinson M, Schmidt DM, Scruth E, Spill GR, Storey CP, Render M, Votto J, Harvey MA. Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference. Crit Care Med. 2012 Feb;40(2):502-9. doi: 10.1097/CCM.0b013e318232da75. Review. — View Citation
Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, Brummel NE, Hughes CG, Vasilevskis EE, Shintani AK, Moons KG, Geevarghese SK, Canonico A, Hopkins RO, Bernard GR, Dittus RS, Ely EW; BRAIN-ICU Study Investigators. Long-term cognitive impairment after critical illness. N Engl J Med. 2013 Oct 3;369(14):1306-16. doi: 10.1056/NEJMoa1301372. — View Citation
Wunsch H, Angus DC, Harrison DA, Collange O, Fowler R, Hoste EA, de Keizer NF, Kersten A, Linde-Zwirble WT, Sandiumenge A, Rowan KM. Variation in critical care services across North America and Western Europe. Crit Care Med. 2008 Oct;36(10):2787-93, e1-9. doi: 10.1097/CCM.0b013e318186aec8. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in Cognitive function | Evaluation of cognitive dysfunction using the Montreal Cognitive Assessment (MOCA) tool, | Change from baseline at the time of discharge from the ICU, 5 days after discharge from the ICU or at the time of hospital discharge (whichever occurs first) and after 3 months of randomization at the follow-up clinic | |
Primary | Change in Psychiatric function | Evaluation of psychiatric dysfunction using the HADS (Hospital Anxiety and Depression Scale). | Change from baseline at the time of discharge from the ICU, 5 days after discharge from the ICU or at the time of hospital discharge (whichever occurs first) and after 3 months of randomization at the follow-up clinic | |
Primary | Change in Post-traumatic stress syndrome | Identification of post-traumatic stress syndrome through PCL-C (Post-traumatic stress checklist-civilian) | Change from baseline at the time of discharge from the ICU, 5 days after discharge from the ICU or at the time of hospital discharge (whichever occurs first) and after 3 months of randomization at the follow-up clinic | |
Primary | Change in physical function | Evaluation of physical dysfunction through FSS-ICU (Functional status score in the ICU) | Change from baseline at the time of discharge from the ICU, 5 days after discharge from the ICU or at the time of hospital discharge (whichever occurs first) and after 3 months of randomization at the follow-up clinic | |
Secondary | The duration of mechanical ventilation, | The duration of mechanical ventilation in days | During ICU stay.. Expected average 21 days | |
Secondary | Duration of sedation | Duration of sedation during ICU stay in days | During ICU stay. Expected average 21 days | |
Secondary | ICU LOS | Length of ICU stay in days | During ICU stay. Up to 30 days | |
Secondary | Hospital Mortality | Hospital LOS in days | 90 days | |
Secondary | Physical function | Measure of handgrip strength though a high precision dynamometer | ICU discharge (baseline) and change from baseline at 3 months |
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