Physiology Clinical Trial
Background Clonidine, a derivate of Imidazol, is an antihypertensive drug. It acts by
stimulating adrenergic receptors on nerves in the brain and Imidazol-receptors. As a result,
clonidine slows the heart rate and reduces blood pressure. Clonidine was approved by the FDA
in 1974 and is registered in Austria with the brand name “Catapresan”.
Alpha2 adrenergic agonists are nowadays used topically as eye drops in glaucoma treatment.
In addition to their known effect of lowering intraocular pressure, alpha2 adrenoceptor
agonists are neuroprotective. Brimonidine, which is the most commonly used topical alpha-2
agonist, is currently on the market for treatment of glaucoma and is effective in reducing
intraocular pressure. It has, however, been shown that brimonidine is a very potent
vasoconstrictor in the ciliary body thus reducing aqueous humor production. Little is,
however, known about potential vasoconstrictor effects of brimonidine in the posterior pole
of the eye. This is of clinical importance, because optic nerve head ischemia appears to
contribute to glaucoma pathophysiology. Direct investigation of the ocular hemodynamic
effects of brimonidine is, however, difficult, because lowering intraocular pressure with
brimonidine may confound the results due to the concomitant change in ocular perfusion
pressure.
The aim of the present study is to assess the effect of intravenous clonidine as model drug
of alpha agonists on ocular blood flow and IOP in healthy humans.
Study objectives:
To investigate effects of clonidine on ocular blood flow and intraocular pressure.
Status | Completed |
Enrollment | 12 |
Est. completion date | January 2005 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 19 Years to 35 Years |
Eligibility |
Inclusion Criteria: Men aged between 19 and 35 years, nonsmokers Body mass index between 15th and 85th percentile Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant Normal laboratory values unless the investigator considers an abnormality to be clinically irrelevant Normal ophthalmic findings, ametropy < 3 Dpt. Exclusion Criteria: Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study Treatment in the previous 3 weeks with any drug Symptoms of a clinically relevant illness in the 3 weeks before the first study day History of hypersensitivity to the trial drug or to drugs with a similar chemical structure History or presence of gastrointestinal, liver or kidney disease, or other conditions known to interfere with, distribution, metabolism or excretion of study drugs Blood donation during the previous 3 weeks History or family history of epilepsy |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Medical University of Vienna |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | ocular blood flow |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04508270 -
Significance of Early Mobilization After VATS-L
|
||
Completed |
NCT05604339 -
Study of Recovery and Blood Rheology Changes in Ultra-endurance Runners (ERUPTION-3)
|
||
Completed |
NCT03705936 -
Metaplasticity in Human Pharyngeal Motor Cortex
|
N/A | |
Completed |
NCT03807258 -
Functional Implication of Corpus Callosum in Voluntary Strength in COPD Patients
|
N/A | |
Active, not recruiting |
NCT02839070 -
Influence of Sleep Regularity on Circadian Rhythms, Learning, Performance, and Mood
|
N/A | |
Completed |
NCT02850367 -
Effect of NO Precursors on Physiological Responses to Exercise
|
N/A | |
Completed |
NCT02778659 -
Hypnotic Intake and Motor and Cognitive Performances at High Altitude
|
N/A | |
Completed |
NCT02408003 -
Changes in Cardiac Deformation Following Physiologic Alterations and Inotropic Support.
|
N/A | |
Recruiting |
NCT02940184 -
GLP-1 Signaling in Truncally Vagotomized Subjects
|
N/A | |
Completed |
NCT03368703 -
Physiopathology of Lower Cortical Activation in COPD Patients: Contribution of Cortical Neuromodulation
|
N/A | |
Completed |
NCT03424551 -
Vibration Induced Reflex Responses and Estimation of TVR
|
N/A | |
Recruiting |
NCT02672722 -
Assessment of the Changes in Cortical and Medullary Renal Blood Flow During Exercise in Healthy Subjects Using Contrast Enhanced Ultrasound
|
Phase 1/Phase 2 | |
Recruiting |
NCT01685307 -
Impact of Cooking Process on Meat Protein Digestion and Metabolism
|
N/A | |
Completed |
NCT01154582 -
Nutritional Quality of Egg Proteins and Effect on Satiety
|
N/A | |
Completed |
NCT05362383 -
Use of TENS for the Recovery of Oral Function After Orthognathic Surgery
|
N/A | |
Recruiting |
NCT05168501 -
Assessing Variability of the Ventilatory Response to Duffin's Rebreathing Procedure
|
N/A | |
Completed |
NCT03751410 -
Chronic Ibrutinib Therapy Effect on Left Atrial Function
|
||
Completed |
NCT01079624 -
GIP and GLP-1 on Gastric Emptying, Appetite and Insulin-glucose
|
Phase 1 | |
Recruiting |
NCT04391465 -
Assessment of the Relationship Between Cerebral Blood Flow and Heart Rate
|
N/A | |
Completed |
NCT03916770 -
The Effect of Whole Body Vibration (WBV) on Spasticity in Poststroke Hemiplegia
|
N/A |