Physical Function Clinical Trial
Official title:
Virtual Reality Motor-cognitive Training for Older People With Cognitive Frailty: The Implementation of the Prototype
NCT number | NCT04730817 |
Other study ID # | K-ZB1H |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | |
Last updated | |
Start date | March 1, 2021 |
Est. completion date | December 2022 |
Cognitive frailty is a clinical syndrome in which cognitive impairment (e.g., poor memory, visuospatial function) and physical frailty (e.g., slowness, poor muscle strength, physical inactivity) co-exist. It is prevalent in community-dwelling older people. The progressive decline of cognitive and physical functions restricts older people from participating in activities (e.g., social get-togethers). Reduced participation further jeopardizes their life-space mobility (e.g., ability to travel to areas far away from home). Therefore, those with cognitive frailty are at risk of developing dementia and becoming dependent. Simultaneous motor-cognitive training is more effective at promoting optimal functioning in older people than motor or cognitive training alone. Gaming is effective at promoting the motivation to participate. The contents of games in the market are unrelated to the context or daily living of the elderly. Currently, available training is non-simultaneous. This makes the training less transferable to the daily life of the elderly and reduces its effects. Virtual reality (VR) technology can provide a virtual space that mimics the real environment. This allows clients to participate in daily activities in a virtual space. Older people can be trained to improve their cognitive and physical skills in a painless, fun way. However, the effect and feasibility of employing simultaneous motor-cognitive training launching on a VR platform mimicking the daily living environment in older people with cognitive frailty is poorly known. Following the findings from the previous proof-of-concept test (registration number: NCT04467216), we proceed to implement the study to 400 participants from six different elderly centres between the period of March 2021 and December 2022.
Status | Recruiting |
Enrollment | 400 |
Est. completion date | December 2022 |
Est. primary completion date | May 31, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 60 Years and older |
Eligibility | Inclusion Criteria: - Age = 60 years, - Self-reported or informant-reported cognitive complaints - Objective cognitive impairment, as defined by a Clinical Dementia Rating of 0.5 and a Montreal Cognitive Assessment (MoCA) score of <25 - Preservation of one's independence, as defined by the Lawton's Instrumental Activity of Daily Living score of >14 - No diagnosed dementia, as observed in the medical record - Physical frailty from being pre-frail to frail, as defined by a Fried Frailty Index (FFI) score of 1-5. Exclusion Criteria: - Participants who have impaired mobility, as defined by Modified Functional Ambulatory Classification (MFAC) < Category 7 (i.e., Outdoor walker), - or probable dementia, i.e., MoCA < 17 or clinical dementia rating = 1. |
Country | Name | City | State |
---|---|---|---|
Hong Kong | Pok Oi Hospital Chan Shi Sau Memorial Social Service Centre | Hong Kong | |
Hong Kong | Pok Oi Hospital Mei Foo Lai Wan Kaifong Association Mr. and Mrs. Leung Chi Chim Elderly Health Support and Learning Centre | Lai Chi Kok | |
Hong Kong | Pok Oi Hospital Mr. Kwok Hing Kwan Neighbourhood Elderly Centre | Lai Chi Kok | |
Hong Kong | Pok Oi Hospital Chan Ping Memorial Neighbourhood Elderly Centre | Tin Shui Wai | |
Hong Kong | Pok Oi Hospital Wong Muk Fung Memorial Elderly Health Support and Learning Centre | Tuen Mun | |
Hong Kong | Pok Oi Hospital Mrs. Wong Tung Yuen District Elderly Community Centre | Yuen Long |
Lead Sponsor | Collaborator |
---|---|
The Hong Kong Polytechnic University | Pok Oi Hospital |
Hong Kong,
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* Note: There are 18 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Global cognitive function | Score on the Montreal Cognitive Assessment Hong Kong Version (HK-MoCA), ranging from 0 to 30. | Change is being assessed at "baseline" (T0) and "immediately after the completion" (T1), being 8 weeks apart | |
Primary | Frailty | Score on the Fried Frailty Phenotype, ranging from 0 to 5 | Change is being assessed at "baseline" (T0) and "immediately after the completion" (T1), being 8 weeks apart | |
Secondary | Inhibition of cognitive interference | Stroop Color-Word Test (SCWT) Global Index score, calculated by I=CW-((W+C)/2) | Change is being assessed at "baseline" (T0) and "immediately after the completion" (T1), being 8 weeks apart | |
Secondary | Executive function | Time taken to complete the trail making test (TMA & TMB), ranges from 0 to 300 seconds (when maximum time is reached) | Change is being assessed at "baseline" (T0) and "immediately after the completion" (T1), being 8 weeks apart | |
Secondary | Verbal and visuo-spatial short-term memory | Score on the Digit Span Test, ranges from 0 to 9 | Change is being assessed at "baseline" (T0) and "immediately after the completion" (T1), being 8 weeks apart | |
Secondary | Walking speed | Timed up and go test (seconds) | Change is being assessed at "baseline" (T0) and "immediately after the completion" (T1), being 8 weeks apart | |
Secondary | Hand grip strength | Hand grip strength by dynamometer (kg) | Change is being assessed at "baseline" (T0) and "immediately after the completion" (T1), being 8 weeks apart |
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