PHP Ia Clinical Trial
Official title:
Effect of Theophylline in Pseudohypoparathyroidism
The study evaluates the effect of theophylline in 100 subjects with Pseudohypoparathyroidism.
It is an open label intervention study for the off-label use of theophylline in psuedohypoparathyroidism (PHP).Theophylline is a is non-specific phosphodiesterase inhibitor which increases the levels of secondary messenger,cAMP. PHP patients have end organ resistance to hormones involving cAMP signaling. Thus, theophylline has a potential to abrogate hormone resistance. Also, it may have a role in bone maturation, neurocognition and metabolism. ;