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Photophobia clinical trials

View clinical trials related to Photophobia.

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NCT ID: NCT06293300 Not yet recruiting - Clinical trials for Traumatic Brain Injury

Understanding and Treating Traumatic Brain Injury (TBI) Associated Photophobia With Botulinum Toxin Type A (BoNT-A)

Start date: August 1, 2024
Phase: Phase 2
Study type: Interventional

The purpose of this research is to understand and treat Traumatic Brain Injury (TBI) associated photophobia (light sensitivity) and its impact on visual function.

NCT ID: NCT06159569 Completed - Dry Eye Clinical Trials

Performance and Tolerability of the Medical Device LACRIACT

Start date: September 9, 2021
Phase: N/A
Study type: Interventional

The goal of this study is testing LACRIACT® eye drops, a medical device, to see how well it works and if people can use it safely. The Investigators will study this in people who have dry eyes, some of whom wear contact lenses, and some who do not. To obtain data from 20 participants, the investigators will first screen 22 patients, as two of them may not meet the requirements. If someone quits the study, the Investigators will not replace them with someone else. A person can partecipate in the study if they meet certain criteria in the study plan, complete the entire treatment, and use eye drops correctly at least 80% of the time. The Investigators running the study might also include up to 10 people who wear soft contact lenses out of the 20 in total. This study will be conducted at a clinic in Italy.

NCT ID: NCT06149000 Not yet recruiting - Migraine Clinical Trials

Migraine Headache Mitigation Utilizing Avulux

Start date: December 13, 2023
Phase: N/A
Study type: Interventional

This will be a randomized double blind cross over interventional trial to determine if Avulux lenses are able to reduce headache symptoms in patients

NCT ID: NCT06109909 Recruiting - Clinical trials for Mild Traumatic Brain Injury

Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury

Start date: January 1, 2024
Phase: N/A
Study type: Interventional

The goal of this study is to complete a pilot study testing the feasibility and acceptability of low-intensity pulse-based transcranial stimulation (LIP-tES) neurofeedback intervention for reducing photosensitivity symptoms in Veterans with a history of mild traumatic brain injury (mTBI). The study will also complete resting-state MRI scans to assess neurophysiological markers of photosensitivity and changes associated with LIP-tES intervention.

NCT ID: NCT05971238 Recruiting - Light Sensitivity Clinical Trials

Eye Movement Behaviour and Pupil Size in Natural Outdoor and Indoor Scenes

Start date: July 1, 2023
Phase: N/A
Study type: Interventional

In this study, the researchers will be using eye tracking and detailed lighting measurements to understand how different types of indoor and outdoor lighting affect the eye movements and pupil sizes of our participants. Participants will be paired up and undergo six eye tracking sessions, split across two appointments. Each appointment will involve viewing either indoor or outdoor scenes, and before each session, participants will spend time adapting to the lighting conditions. Overall, each participant will spend 24 minutes being tracked, and the entire study will take about 2-3 hours to complete. The investigators expect differences in eye movements and pupil size between indoor and outdoor scenes.

NCT ID: NCT05829135 Recruiting - Visual Impairment Clinical Trials

Improving Glare and Visual Comfort for Patients With Visual Impairment

Start date: May 1, 2023
Phase: N/A
Study type: Interventional

To assess the use of contact lenses with transitions technology to improve glare, light sensitivity and overall visual comfort in patients with visual impairment.

NCT ID: NCT05369910 Completed - Migraine Disorders Clinical Trials

How Can we Treat Photophobia in Migraine

Start date: April 1, 2015
Phase: N/A
Study type: Interventional

Photophobia, the aberrantly increased sensitivity to light, is a common symptom in migraine patients and light discomfort is frequently found as a trigger for migraine attacks. In behavioral studies, planned exposure to light was found to reduce headache in migraineurs with photophobia, potentially by increasing habituation to this migraine trigger. Here, neurophysiological mechanisms of light exposure versus light deprivation therapy in migraine patients are investigated using functional magnetic resonance imaging (fMRI). Migraine patients and healthy controls receive light exposure therapy (Flash) and light deprivation therapy (Dark) for one hour daily on 7 consecutive days, in a crossover design with a wash-out period of three months. Study participants keep a diary including items on interictal and ictal photophobia, headache frequency and severity 7 days before, during, and 7 days after the interventions. One week before and one day after both interventions, fMRI using flickering light in a block design is applied. Functional activation is analyzed at whole-brain level and habituation of the visual cortex (V1) is modeled with the initial amplitude estimate and the corrected habituation slope.

NCT ID: NCT05207865 Active, not recruiting - Migraine Clinical Trials

Safety and Tolerability Study of Daily Dosing Rimegepant in Episodic Migraine Prevention

Start date: March 15, 2022
Phase: Phase 4
Study type: Interventional

The purpose of this study is to further evaluate the long-term safety and tolerability of daily dosing of rimegepant for the prevention of episodic migraine.

NCT ID: NCT04811079 Completed - Photosensitivity Clinical Trials

The Role of Spectral Filtering in a Spectrally Adjustable Ocular Photosensitivity Analyzer

Start date: July 14, 2021
Phase: N/A
Study type: Interventional

This is a 6-visit, single-center, non-dispensing, randomized, single-masked, 5×5 crossover study. Subjects will participate in 6 scheduled over the duration of approximately 10.5 months.

NCT ID: NCT04251234 Terminated - Bipolar Disorder Clinical Trials

Light at Night Study

LAN
Start date: October 15, 2020
Phase: N/A
Study type: Interventional

The purpose of this mechanistic study is to examine light sensitivity (melatonin suppression) in people with bipolar depression I, and compare it to healthy controls. This is not a treatment study.