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Clinical Trial Summary

The purpose of this study is testing the use of topical Imipramine in combination with topical photodynamic therapy's (PDT) effect on pain following treatment. PDT is a commonly used treatment in dermatology for patients who have many pre-cancers (actinic keratosis-AKs) on their skin. These are both FDA-approved treatments, but this study is evaluating their use in combination, which has not been evaluated in the past. The investigators have been doing studies using animals that suggest that imipramine might make the PDT less painful and might help it work better. In order to participate, the subject and their dermatologist have decided that they would benefit from PDT to treat their skin due to many AK precancerous lesions. Please note that neither PDT nor imipramine are experimental treatments, but treating their skin with imipramine before PDT is a new approach.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05688904
Study type Interventional
Source Wright State University
Contact Manager, Clinical Research Operations
Phone 937-245-7500
Email pturesearch@wrightstatephysicians.org
Status Recruiting
Phase Phase 1
Start date January 19, 2023
Completion date March 2028

See also
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