Clinical Trials Logo
  1. Home
  2. Photodynamic Therapy
  3. NCT03960125

Photodynamic Therapy and Microvesicles

Photodynamic Therapy Clinical Trial

Official title:
Photodynamic Therapy and Microvesicles

Clinical Trial Summary

This study is designed to test whether localized photodynamic therapy (PDT) treatment will result in increased skin levels of microvesicle particle (MVP) and if the use of imipramine will counteract PDT generated MVP release. The effects of PDT and ultraviolet B radiation (UVB) on platelet-activating factor (PAF) and MVP production have long been part of the PI's research experience. To test this, the investigator plans to enroll up to enroll up to 12 male subjects whom are aged 21 to age 45. These subjects will be treated with topical 5-aminolevulinic acid gel (Ameluz) to small areas of forearm followed by treatment with blue light. The areas will then be treated with either 4% imipramine cream or cream base as control. Four hours later, the redness of the areas will be measured using a mexameter and MVPs measured in skin biopsies taken from PDT-treated skin.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03960125
Study type Interventional
Source Wright State University
Contact
Status Withdrawn
Phase Early Phase 1
Start date March 29, 2021
Completion date September 2022
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06052033 - Comparison of 5-ALA Photodynamic Therapy and CO2 Laser for Treating Persistent Low-Grade Cervical Lesions With High-Risk HPV Infection N/A
Recruiting NCT05031923 - Treatment of Intrabony Defects With Simvastatin and Antimicrobial Photodynamic Therapy N/A
Completed NCT04037709 - Photodynamic Therapy in Patients With Gingivitis N/A
Recruiting NCT05043935 - The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis N/A
Not yet recruiting NCT06437288 - Hematoporphyrin Photodynamic Therapy for Esophageal Cancer Phase 2
Completed NCT01756313 - Optimizing Uptake of Methylaminolevulinat With Fractional Ablative Laser Technique Phase 4
Recruiting NCT01349361 - Treatment of Basal Cell Carcinomas With Methyl Aminolevulinate and Daylight Phase 2
Not yet recruiting NCT06468540 - Combination of Micropulse Laser With or Without Photodynamic Therapy for Chronic Central Serous Chorioretinopathy
Recruiting NCT05688904 - The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy Phase 1
Recruiting NCT06445699 - Photodynamic Therapy With Hydrogel Dressing for Chronic Wounds N/A
Completed NCT04037475 - Treatment of Herpes Labialis by Photodynamic Therapy N/A
Recruiting NCT04689243 - Low Concentration ALA-PDT in Treatment of Skin Ulcer N/A
Recruiting NCT06311890 - Study to Evaluate the Efficacy, Safety and Tolerability of Photodynamic Therapy(PDT) With Chlorin-e6 in Treating Moderate to Severe Acne Phase 2
Enrolling by invitation NCT05820750 - Clinical and Radiographic Evaluation of Photodynamic Therapy for Root Canal Treatment of Primary Molars N/A
Enrolling by invitation NCT04223570 - Portable Measurement of Protoporphyrin IX in the Skin
Completed NCT03643744 - Photodynamic Therapy-Induced Immune Modulation: Part III Phase 1